Main Street in the context of Metonym

Commercial area, commercial district or commercial zone in a city is an area, district, or neighborhoods primarily composed of commercial buildings, such as a strip mall, office parks, downtown, central business district, financial district, "Main Street", or shopping centers. Commercial activity within cities includes the buying and selling of goods and services in retail businesses, wholesale buying and selling, financial establishments, and a wide variety of uses that are broadly classified as "business." While commercial activities typically take up a relatively small amount of land, they are extremely important to a community's economy. They provide employment, facilitate the circulation of money, and often serve many other roles important to the community, such as public gathering and cultural events.

A commercial area is real estate intended for use by for-profit businesses, such as office complexes, shopping malls, service stations, bars and restaurants. It may be purchased outright by a developer for future projects or leased through a real estate broker. This type of property falls somewhere between residential and industrial property.Practically every incomer must grant permission to build a new office complex or other profit-making business, the city government must determine that the chosen area is indeed commercial area. If the zones which separate commercial, industrial, and residential area are clearly zoned for commercial use, the city will allow the sale to proceed for the stated use. If any part of the property extends into a residential or industrial zone, however, then the buyer must seek a 'variance', special permission to cross over a zone boundary.

125th Street, co-named Martin Luther King Jr. Boulevard is a two-way street that runs east–west in the New York City borough of Manhattan, from First Avenue on the east to Marginal Street, a service road for the Henry Hudson Parkway along the Hudson River in the west. It is often considered to be the "Main Street" of Harlem.

Notable buildings along 125th Street include the Apollo Theater, the Adam Clayton Powell Jr. State Office Building, the Hotel Theresa, the Studio Museum in Harlem, the Mount Morris Bank Building, Harlem Commonwealth Council, the Harlem Children's Zone, the Church of St. Joseph of the Holy Family, and the former West End Theatre, now home to the La Gree Baptist Church.

40°43′11″N 73°59′47″W / 40.7196°N 73.9963°W / 40.7196; -73.9963

Mott Street (Chinese: 勿街; Jyutping: Mat6 gaai1) is a narrow but busy thoroughfare that runs in a north–south direction in the New York City borough of Manhattan. It is regarded as Chinatown's unofficial "Main Street". Mott Street runs from Bleecker Street in the north to Chatham Square in the south. It is a one-way street with southbound-running vehicular traffic only.