Mahmud Nedim Pasha in the context of "List of Ottoman Grand Viziers"

The Mutasarrifate of Jerusalem (Ottoman Turkish: قُدس شَرِيف مُتَصَرِّفلغى, Kudüs-i Şerif Mutasarrıflığı; Arabic: متصرفية القدس الشريف, Mutaṣarrifiyyat al-quds aš-šarīf, French: Moutassarifat de Jérusalem), also known as the Sanjak of Jerusalem, was a district in Ottoman Syria with special administrative status established in 1872. The district encompassed Jerusalem as well as Hebron, Jaffa, Gaza and Beersheba. Many documents during the Late Ottoman period refer to the Mutasarrifate of Jerusalem as Palestine; one such describes Palestine as including the Sanjak of Nablus and Sanjak of Akka (Acre) as well, more in line with European usage. It was the seventh most heavily populated region of the Ottoman Empire's 36 provinces.

The district was separated from the Damascus Eyalet and placed directly under the supervision of the Ottoman central government in Constantinople (now Istanbul) in 1841, and formally created as an independent province in 1872 by Grand Vizier Mahmud Nedim Pasha. Scholars provide a variety of reasons for the separation, including increased European interest in the region, and strengthening of the southern border of the Empire against the Khedivate of Egypt. Initially, the Mutasarrifate of Acre and Mutasarrifate of Nablus were combined with the province of Jerusalem, with the combined province being referred to in the register of the court of Jerusalem as the "Jerusalem Eyalet", and referred to by the British consul as the creation of "Palestine into a separate eyalet". After less than two months, the sanjaks of Nablus and Acre were separated and added to the Vilayet of Beirut, leaving just the Mutasarrifate of Jerusalem. In 1906, the Kaza of Nazareth was added to the Jerusalem Mutasarrifate as an exclave, primarily in order to allow the issuance of a single tourist permit to Christian travellers.