Madrid Atocha railway station in the context of Museo Nacional Centro de Arte Reina Sofía

The Museo Nacional Centro de Arte Reina Sofía ("Queen Sofía National Museum Art Centre"; MNCARS) is Spain's national museum of 20th-century art. The museum was officially inaugurated on September 10, 1992, and is named for Queen Sofía. It is located in Madrid, near the Atocha train and metro stations, at the southern end of the so-called Golden Triangle of Art (located along the Paseo del Prado and also comprising the Museo del Prado and the Museo Thyssen-Bornemisza).

The museum is mainly dedicated to Spanish art. Highlights of the museum include collections of Spain's two greatest 20th-century masters, Pablo Picasso and Salvador Dalí. The most famous masterpiece in the museum is Picasso's 1937 painting Guernica. Along with its extensive collection, the museum offers a mixture of national and international temporary exhibitions in its many galleries, making it one of the world's largest museums for modern and contemporary art. In 2021, due to the COVID-19 pandemic restrictions, it attracted 1,643,108 visitors, up 32 percent from 2020, but well below 2019 attendance. In 2021 it ranked eighth on the list of most-visited art museums in the world.

The Paseo del Prado is one of the main boulevards in Madrid, Spain. It runs north–south between the Plaza de Cibeles and the Plaza del Emperador Carlos V (also known as Plaza de Atocha), with the Plaza de Cánovas del Castillo (the location of the Fuente de Neptuno, and of the Ritz and Palace five-star hotels) lying approximately in the middle. The Paseo del Prado forms the southern end of the city's central axis (which continues to the north of Cibeles as the Paseo de Recoletos, and further north as the Paseo de la Castellana). It enjoys the status of Bien de Interés Cultural (BIC), and as part of a combined UNESCO World Heritage Site with Buen Retiro Park.