Lo Spagna (died c. 1529), "the Spaniard" in Italian, was a painter of the Renaissance, active in central Italy. His name was Giovanni di Pietro, but he was known as Lo Spagna because he was of Spanish heritage. He was an important assistant and follower of the Umbrian painter Perugino, whose style his paintings developed. He should not be confused with Pietro di Giovanni D'Ambrogio of Siena.
Lo Spagna is known for a number of major works completed in the region, including the Birth of the Virgin from Spineta in Todi, the Adoration of the Magi of Ferentillo and the Nativity of St Anthony in Perugia. Lo Spagna married Santina Martorelli from one of Spoleto's leading families and here he was nominated Capitano delle Arti dei Pittori e degli Orefici in 1517. He died in 1528, possibly of the plague.
