List of cities in Colombia in the context of "Cúcuta"

Medellín (/ˌmɛdeɪˈ(j)iːn/ MED-ay-(Y)EEN; Spanish: [meðeˈʝin] or [meðeˈʎin]), officially the Special District of Science, Technology and Innovation of Medellín (Spanish: Distrito Especial de Ciencia, Tecnología e Innovación de Medellín), is the second-largest city in Colombia after Bogotá, and the capital of the department of Antioquia. It is located in the Aburrá Valley, a central region of the Andes Mountains, in northwestern South America. The city's population was 2,427,129 at the 2018 census. The metro area of Medellín is the second-largest urban agglomeration in Colombia in terms of population and economy, with more than 4 million people.

In 1616, the Spaniard Francisco de Herrera Campuzano erected a small indigenous village (poblado) known as "Saint Lawrence of Aburrá" (San Lorenzo de Aburrá), located in the present-day El Poblado commune. On 2 November 1675, the queen consort Mariana of Austria founded the "Town of Our Lady of Candelaria of Medellín" (Villa de Nuestra Señora de la Candelaria de Medellín) in the Aná region, which today corresponds to the center of the city (east-central zone) and first describes the region as "Medellín". In 1826, the city was named the capital of the Department of Antioquia by the National Congress of the nascent Republic of Gran Colombia, comprising present-day Colombia, Venezuela, Ecuador, and Panama. After Colombia won its independence from Spain, Medellín became the capital of the Federal State of Antioquia until 1888, with the proclamation of the Colombian Constitution of 1886. During the 19th century, Medellín was a dynamic commercial center, first exporting gold, then producing and exporting coffee.

Cartagena (/ˌkɑːrtəˈhɛnə/ KAR-tə-HEN-ə), known since the colonial era as Cartagena de Indias (Spanish: [kaɾtaˈxena ðe ˈindjas] ), is a city and one of the major ports on the northern coast of Colombia in the Caribbean Coast Region, along the Caribbean Sea. Cartagena's past role as a link in the route to the West Indies provides it with important historical value for world exploration and preservation of heritage from the great commercial maritime routes. As a former Spanish colony, it was a key port for the export of Bolivian silver to Spain and for the import of enslaved Africans under the asiento system. It was defensible against pirate attacks in the Caribbean. The city's strategic location between the Magdalena and Sinú rivers also gave it easy access to the interior of New Granada and made it a main port for trade between Spain and its overseas empire, establishing its importance by the early 1540s.

Modern Cartagena is the capital of the Bolívar Department, and had a population of 876,885 according to the 2018 census, making it the second-largest city in the Caribbean region, after Barranquilla, and the fifth-largest city in Colombia. The metropolitan area of Cartagena is the sixth-largest urban area in the country, after metropolitan area of Bucaramanga. Economic activities include the maritime and petrochemical industries, as well as tourism.

Santa Marta (Spanish pronunciation: [ˌsanta ˈmaɾta]), officially the Distrito Turístico, Cultural e Histórico de Santa Marta (English: Historic, Cultural & Tourist District of Santa Marta), is a port city on the coast of the Caribbean Sea in northern Colombia. It is the capital of Magdalena Department and the fourth-largest urban city of the Caribbean Region of Colombia, after Barranquilla, Cartagena, and Soledad. Founded on July 29, 1525, by the Spanish conqueror Rodrigo de Bastidas, it was one of the first Spanish settlements in Colombia, its oldest surviving city, and second-oldest in South America. This city is situated on a bay by the same name and as such, it is a prime tourist destination in the Caribbean region.