The Liquiñe-Ofqui Fault is major geological fault that runs a length of roughly 1,200 kilometres (750 mi) in a NNE-SSW orientation and exhibits current seismicity. It is located in the Chilean Northern Patagonian Andes. It is a dextral intra-arc strike-slip fault. Most large stratovolcanoes of the Southern Volcanic Zone of the Andes are aligned by the fault which allows for the movement of magma and hydrothermal fluids.
The fault crosses several transverse faults including the Mocha-Villarrica Fault Zone (MVFZ) and the Biobío-Aluminé Fault Zone. The fault has had periods of ductile deformation associated to pluton emplacement, be it either at great depths or by shallow intrusions.