Leo Szilard in the context of "Maxwell's demon"

The Einstein–Szilard letter was a letter written by Leo Szilard and signed by Albert Einstein on August 2, 1939, that was sent to President of the United States Franklin D. Roosevelt. Written by Szilard in consultation with fellow Hungarian physicists Edward Teller and Eugene Wigner, the letter warned that Germany might develop atomic bombs and suggested that the United States start its own nuclear program. It prompted action by Roosevelt, which eventually resulted in the Manhattan Project, the development of the first atomic bombs, and the use of these bombs on the cities of Hiroshima and Nagasaki.

Chicago Pile-1 (CP-1) was the first artificial nuclear reactor. On 2 December 1942, the first human-made self-sustaining nuclear chain reaction was initiated in CP-1 during an experiment led by Enrico Fermi. The secret development of the reactor was the first major technical achievement for the Manhattan Project, the Allied effort to create nuclear weapons during World War II. Developed by the Metallurgical Laboratory at the University of Chicago, CP-1 was built under the west viewing stands of the original Stagg Field. Although the project's civilian and military leaders had misgivings about the possibility of a disastrous runaway reaction, they trusted Fermi's safety calculations and decided they could carry out the experiment in a densely populated area. Fermi described the reactor as "a crude pile of black bricks and wooden timbers".

After a series of attempts, the successful reactor was assembled in November 1942 by a team of about 30 that, in addition to Fermi, included scientists Leo Szilard (who had previously formulated an idea for non-fission chain reaction), Leona Woods, Herbert L. Anderson, Walter Zinn, Martin D. Whitaker, and George Weil. The reactor used natural uranium. This required a very large amount of material in order to reach criticality, along with graphite used as a neutron moderator. The reactor contained 45,000 ultra-pure graphite blocks weighing 360 short tons (330 tonnes) and was fueled by 5.4 short tons (4.9 tonnes) of uranium metal and 45 short tons (41 tonnes) of uranium oxide. Unlike most subsequent nuclear reactors, it had no radiation shielding or cooling system as it operated at very low power – about one-half watt; nonetheless, the reactor's success meant that a chain reaction could be controlled and the nuclear reaction studied and put to use.

A salted bomb is a nuclear weapon designed to function as a radiological weapon by producing larger quantities of radioactive fallout than unsalted nuclear arms. This fallout can render a large area uninhabitable. The term is derived both from the means of their manufacture, which involves the incorporation of additional elements (eg, sodium-23) to a standard atomic weapon, and from the expression "to salt the earth", meaning to render an area uninhabitable for generations. The idea originated with Hungarian-American physicist Leo Szilard, in February 1950. His intent was not to propose that such a weapon be built, but to show that nuclear weapon technology would soon reach the point where it could end human life on Earth.

No intentionally salted bomb has ever been atmospherically tested, and as far as is publicly known, none has ever been built. However, the UK tested a one-kiloton bomb incorporating a small amount of cobalt as an experimental radiochemical tracer at their Tadje testing site in Maralinga range, Australia, on September 14, 1957. The Soviet triple "taiga" nuclear salvo test, as part of the preliminary March 1971 Pechora–Kama Canal project, converted significant amounts of stable cobalt-59 to radioactive cobalt-60 by fusion-generated neutron activation and this product is responsible for about half of the gamma dose measured at the test site in 2011. The experiment was regarded as a failure and was not repeated.

"The Martians" (Hungarian: "A marslakók") were a group of prominent scientists (mostly, but not exclusively, physicists and mathematicians) of Hungarian Jewish descent who emigrated from Europe to the United States in the early half of the 20th century.

Leo Szilard jokingly suggested that Hungary was a front for aliens from Mars. In an answer to the question of why there is no evidence of intelligent life beyond Earth (called the Fermi paradox) despite its high probability of existence, Szilárd responded: "They are already here among us – they just call themselves Hungarians." This account is featured in György Marx's book The Voice of the Martians.