The La Cordillera Reef Nature Reserve (Spanish: Reserva Natural Arrecifes de la Cordillera) is a nature reserve consisting of La Cordillera (''the mountain range''), a small chain of cays, reefs, and skerries in the northeast of the archipelago and island of Puerto Rico. Located about 1 mile (0.87 nmi) off the coast of the municipality of Fajardo, the reserve extends about 15 miles (13 nmi) and 30,000 acres between Las Cabezas de San Juan cape in Fajardo and the island-municipality of Culebra in the Virgin Islands. From west to east, it comprises Las Cucarachas and Los Farallones skerries, Icacos, Ratones, and Lobos cays, Palominos and Palominitos islands, La Blanquilla and Diablo cays, and Hermanos and Barriles reefs, all of which cover about 218 acres of land.
With the exception of Palominos island and Lobos cay, which are privately owned, all cays, reefs, and skerries in the small chain are protected by the marine reserve. The nature reserve is also important for local fishermen and eastern coastal municipalities, including Fajardo, Ceiba, and Naguabo, which depend on the reserve for their fishing industries.