La'ilay Maychew (Tigrinya: ላዕላይ ማይጨው, transl. "Upper Salty Water") is a woreda in Tigray Region, Ethiopia. Part of the Maekelay Zone (central), La'ilay Maychew is bordered on the south by Naeder Adet, on the west by Tahtay Maychew, on the north by Mereb Lehe, and on the east by Adwa. The town of Axum is surrounded by La'ilay Maychew; other towns in La'ilay Maychew include Mahibere Degue.
High points in this woreda include Bet Giyorgis (2450 meters) and May Koho (2335 meters).
