The Klastline River is a tributary of the Stikine River in northwestern British Columbia, Canada. It flows generally northwest about 70 km (43 mi) to join the Stikine River, which flows southwest across the Canada–United States border into Alaska where it empties into various straits of the Inside Passage. The Klastline River flows through Mount Edziza Provincial Park which lies within the traditional territory of the Tahltan people. Klastline means "confluence" or "junction of waters" in the Tahltan language.
The Klastline River's watershed covers 1,841 km (711 sq mi) and its estimated mean annual discharge is 21.5 m/s (760 cu ft/s). The mouth of the Klastline River is located about 27 km (17 mi) northeast of Telegraph Creek, about 52 km (32 mi) northwest of Iskut and about 64 km (40 mi) southwest of Dease Lake. The Klastline River's watershed's land cover is classified as 45% conifer forest, 21.2% shrubland, 11.9% barren, 8.2% mixed forest, 7.6% herbaceous, and small amounts of other cover.