Kingdom of Pergamum in the context of "Lysimachus"

Classical Anatolia is Anatolia during classical antiquity. Early in that period, Anatolia was divided into several Iron Age kingdoms, most notably Lydia in the west, Phrygia in the center and Urartu in the east. Anatolia fell under Achaemenid Persian rule c. 550 BC. In the aftermath of the Greco-Persian Wars, all of Anatolia remained under Persian control except for the Aegean coast, which was incorporated in the Delian League in the 470s BC. Alexander the Great finally wrested control of the whole region from Persia in the 330s BC. After Alexander's death, his conquests were split amongst several of his trusted generals, but were under constant threat of invasion from both the Gauls and other powerful rulers in Pergamon, Pontus, and Egypt.

The Seleucid Empire, the largest of Alexander's territories, and which included Anatolia, became involved in a disastrous war with Rome culminating in the battles of Thermopylae and Magnesia. The resulting Treaty of Apamea in (188 BC) saw the Seleucids retreat from Anatolia. The Kingdom of Pergamum and the Republic of Rhodes, Rome's allies in the war, were granted the former Seleucid lands in Anatolia. Anatolia subsequently became contested between the neighboring rivalling Romans and the Parthian Empire, which frequently culminated in the Roman–Parthian Wars.

Hellenistic Greece is the historical period of Ancient Greece following Classical Greece and between the death of Alexander the Great in 323 BC and the annexation of the classical Greek Achaean League heartlands by the Roman Republic. This culminated at the Battle of Corinth in 146 BC, a crushing Roman victory in the Peloponnese that led to the destruction of Corinth and ushered in the period of Roman Greece. Hellenistic Greece's definitive end was with the Battle of Actium in 31 BC, when Octavian defeated Ptolemaic queen Cleopatra VII and Mark Antony, the next year taking over Alexandria, the last great center of Hellenistic Greece.

The Hellenistic period began with the wars of the Diadochi, armed contests among the former generals of Alexander the Great to carve up his empire in Europe, Asia, and North Africa. The wars lasted until 275 BC, witnessing the fall of both the Argead and Antipatrid dynasties of Macedonia in favor of the Antigonid dynasty. The era was also marked by successive wars between the Kingdom of Macedonia, the kingdom of Epirus, the Aetolian League, Achaean League, Sparta, Rhodes, kingdom of Pergamum as well as the Seleucid and Ptolemaic empires.