The D'Entrecasteaux Channel /ˌdɒntrəˈkæstoʊ/ is a body of water located between Bruny Island and the south-east of mainland Tasmania, Australia. The channel forms the estuarine mouth for both the Derwent and Huon Rivers and empties into the Tasman Sea of the South Pacific Ocean. It was sighted by Abel Tasman in 1642 and later surveyed in 1792 by Bruni d'Entrecasteaux.
Towns along the channel include Margate, Snug, Kettering, Woodbridge, Flowerpot, Middleton and Gordon.