Ketanserin in the context of Serotonin

Ketanserin in the context of Serotonin

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⭐ Core Definition: Ketanserin

Ketanserin, sold under the brand name Sufrexal, is an antihypertensive agent which is used to treat arterial hypertension and vasospastic disorders. It is also used in scientific research as an antiserotonergic agent in the study of the serotonin system; specifically, the 5-HT2 receptor family. The drug is taken by mouth.

Side effects of ketanserin include dizziness, tiredness, edema, dry mouth, weight gain, and QT interval prolongation. Ketanserin acts as a selective antagonist of the serotonin 5-HT2A, α1-adrenergic, and histamine H1 receptors. It also shows lower affinity for various other targets.

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Ketanserin in the context of Mescaline

Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, found in cacti like peyote (Lophophora williamsii) and San Pedro (certain species of the genus Echinopsis) and known for its serotonergic hallucinogenic effects.

Mescaline is typically taken orally and used recreationally, spiritually, and medically, with psychedelic effects occurring at doses from 100 to 1,000 mg, including microdosing below 75 mg, and it can be consumed in pure form or via mescaline-containing cacti. Mescaline induces a psychedelic experience characterized by vivid visual patterns, altered perception of time and self, synesthesia, and spiritual effects, with an onset of 0.5 to 0.9 hours and a duration that increases with dose, ranging from about 6 to 14 hours. Ketanserin blocks mescaline’s psychoactive effects, and while it's unclear if mescaline is metabolized by monoamine oxidase enzymes, preliminary evidence suggests harmala alkaloids may potentiate its effects.

View the full Wikipedia page for Mescaline
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LINKED FROM (PARENTS)
← Mescaline
LINKS TO (CHILDREN)
Antihypertensive agent → Arterial hypertension → Vasospasm → Scientific research → Antiserotonergic → Medication → Serotonin → 5-HT2 receptor → Oral administration → Side effect → Dizziness → Tiredness → Edema → Dry mouth → Weight gain → Drug-induced QT prolongation → Binding selectivity → Receptor antagonist → 5-HT2A receptor → Α1-adrenergic receptor → Histamine → H1 receptor → Affinity (pharmacology) → Biological target →