Keratin in the context of Monomer


Keratin in the context of Monomer

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⭐ Core Definition: Keratin

Keratin (/ˈkɛrətɪn/) is one of a family of structural fibrous proteins also known as scleroproteins. It is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin in tetrapod vertebrates. Keratin also protects epithelial cells from damage or stress. Keratin is extremely insoluble in water and organic solvents. Keratin monomers assemble into bundles to form intermediate filaments, which are tough and form strong unmineralized epidermal appendages found in reptiles, birds, amphibians, and mammals. Excessive keratinization participate in fortification of certain tissues such as in horns of cattle and rhinos, and armadillos' osteoderm. The only other biological matter known to approximate the toughness of keratinized tissue is chitin.Keratin comes in two types: the primitive, softer forms found in all vertebrates and the harder, derived forms found only among sauropsids (reptiles and birds).

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Keratin in the context of Chytridiomycota

Chytridiomycota are a division of zoosporic organisms in the kingdom Fungi, informally known as chytrids. The name is derived from the Ancient Greek χυτρίδιον (khutrídion), meaning "little pot", describing the structure containing unreleased zoospores. Chytrids are one of the earliest diverging fungal lineages, and their membership in kingdom Fungi is demonstrated with chitin cell walls, a posterior whiplash flagellum, absorptive nutrition, use of glycogen as an energy storage compound, and synthesis of lysine by the α-amino adipic acid (AAA) pathway.

Chytrids are saprobic, degrading refractory materials such as chitin and keratin, and sometimes act as parasites. There has been a significant increase in the research of chytrids since the discovery of Batrachochytrium dendrobatidis, the causal agent of chytridiomycosis.

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Keratin in the context of Pangolin

Pangolins, sometimes known as scaly anteaters, are mammals of the order Pholidota (/fɒlɪˈdtə/). The one extant family, the Manidae, has three genera: Manis, Phataginus, and Smutsia. Manis comprises four species found in Asia, while Phataginus and Smutsia include two species each, all found in sub-Saharan Africa. These species range in size from 30 to 100 cm (12 to 39 in). Several extinct pangolin species are also known. In September 2023, nine species were reported.

Pangolins have large, protective keratin scales, similar in material to fingernails and toenails, covering their skin; they are the only known mammals with this feature. Depending on the species, they live in hollow trees or burrows. Pangolins are nocturnal, and their diet consists of mainly ants and termites, which they capture using their long tongues. They tend to be solitary animals, meeting only to mate and produce a litter of one to three offspring, which they raise for about two years. Pangolins superficially resemble armadillos, though the two are not closely related; they have undergone convergent evolution.

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Keratin in the context of William Astbury

William Thomas Astbury FRS (25 February 1898 – 4 June 1961) was an English physicist and molecular biologist who made pioneering X-ray diffraction studies of biological molecules. His work on keratin provided the foundation for Linus Pauling's discovery of the α-helix. He also studied the structure for DNA in 1937 and made the first step in the elucidation of its structure.

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Keratin in the context of Scale (anatomy)

In zoology, a scale (Ancient Greek: λεπίς, romanizedlepís; Latin: squāma) is a small rigid plate made out of keratin that grows out of vertebrate animals' skin to provide protection. In lepidopterans (butterflies and moths), scales are plates on the surface of the insect wing, made out of chitin instead of keratin, and provide coloration. Scales are quite common and have evolved multiple times through convergent evolution, with varying structure and function.

Scales are generally classified as part of an organism's integumentary system. There are various types of scales according to the shape and class of an animal.

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Keratin in the context of Turtle

Turtles (order Testudines) are reptiles characterized by a special shell developed mainly from their ribs. Modern turtles are divided into two major groups, the Pleurodira (side necked turtles) and Cryptodira (hidden necked turtles), which differ in the way the head retracts. There are 360 living and recently extinct species of turtles, including land-dwelling tortoises and freshwater terrapins. They are found on most continents, some islands and, in the case of sea turtles, much of the ocean. Like other amniotes (reptiles, birds, and mammals) they breathe air and do not lay eggs underwater, although many species live in or around water.

Turtle shells are made mostly of bone; the upper part is the domed carapace, while the underside is the flatter plastron or belly-plate. Its outer surface is covered in scales made of keratin, the material of hair, horns, and claws. The carapace bones develop from ribs that grow sideways and develop into broad flat plates that join up to cover the body. Turtles are ectotherms or "cold-blooded", meaning that their internal temperature varies with their direct environment. They are generally opportunistic omnivores and mainly feed on plants and animals with limited movement. Many turtles migrate short distances seasonally. Sea turtles are the only reptiles that migrate long distances to lay their eggs on a favored beach.

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Keratin in the context of Bovidae

Bovidae is the biological family of cloven-hoofed, ruminant mammals that includes cattle, bison, buffalo, antelopes, and goat-antelopes such as sheep and goats. There are 143 extant species and 300 known extinct species of bovids, which are divided into either 11 major subfamilies, or two subfamilies with thirteen tribes. The earliest known bovid had evolved by 20 million years ago, in the early Miocene.

The bovids show great variation in size and colouration of their fur. With exceptions in some domesticated forms, all male bovids have two or more horns, and in many species, females possess horns too. The size and shape of the horns vary greatly, but the basic structure is always one or more pairs of simple, unbranched, bony protrusions of the skull covered in a permanent sheath of keratin, and often with a spiral, twisted, or fluted shape, Most bovids bear 30 to 32 teeth.

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Keratin in the context of Chitin

Chitin (C8H13O5N)n (/ˈktɪn/ KY-tin) is a long-chain polymer of N-acetylglucosamine, an amide derivative of glucose. Chitin is the second most abundant polysaccharide in nature (behind only cellulose); an estimated 1 billion tons of chitin are produced each year in the biosphere. It is a primary component of cell walls in fungi (especially filamentous and mushroom-forming fungi), the exoskeletons of arthropods such as crustaceans and insects, the radulae, cephalopod beaks and gladii of molluscs and in some nematodes and diatoms.It is also synthesised by at least some fish and lissamphibians. Commercially, chitin is extracted from the shells of crabs, shrimps, shellfish and lobsters, which are major by-products of the seafood industry. The structure of chitin is comparable to cellulose, forming crystalline nanofibrils or whiskers. It is functionally comparable to the protein keratin. Chitin has proved useful for several medicinal, industrial and biotechnological purposes.

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Keratin in the context of Cell culture

Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. After cells of interest have been isolated from living tissue, they can subsequently be maintained under carefully controlled conditions. They need to be kept at body temperature (37 °C) in an incubator. These conditions vary for each cell type, but generally consist of a suitable vessel with a substrate or rich medium that supplies the essential nutrients (amino acids, carbohydrates, vitamins, minerals), growth factors, hormones, and gases (CO2, O2), and regulates the physio-chemical environment (pH buffer, osmotic pressure, temperature). Most cells require a surface or an artificial substrate to form an adherent culture as a monolayer (one single-cell thick), whereas others can be grown free floating in a medium as a suspension culture. This is typically facilitated via use of a liquid, semi-solid, or solid growth medium, such as broth or agar. Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. The lifespan of most cells is genetically determined, but some cell-culturing cells have been 'transformed' into immortal cells which will reproduce indefinitely if the optimal conditions are provided.

In practice, the term "cell culture" now refers to the culturing of cells derived from multicellular eukaryotes, especially animal cells, in contrast with other types of culture that also grow cells, such as plant tissue culture, fungal culture, and microbiological culture (of microbes). The historical development and methods of cell culture are closely interrelated with those of tissue culture and organ culture. Viral culture is also related, with cells as hosts for the viruses.

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Keratin in the context of Horn (anatomy)

A horn is a permanent pointed projection on the head of various animals that consists of a covering of keratin and other proteins surrounding a core of live bone. Horns are distinct from antlers, which are not permanent. In mammals, true horns are found mainly among the ruminant artiodactyls, in the families Antilocapridae (pronghorn) and Bovidae (cattle, goats, antelope etc.). Cattle horns arise from subcutaneous connective tissue (under the scalp) and later fuse to the underlying frontal bone.

One pair of horns is usual; however, two or more pairs occur in a few wild species and in some domesticated breeds of sheep. Polycerate (multi-horned) sheep breeds include the Hebridean, Icelandic, Jacob, Manx Loaghtan, and the Navajo-Churro.

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Keratin in the context of Bog bodies

A bog body is a human cadaver that has been naturally mummified in a peat bog. Such bodies, sometimes known as bog people, are both geographically and chronologically widespread, having been dated between 8000 BC and the Second World War. The common factors of bog bodies are that they have been found in peat and are at least partially preserved. However, the actual levels of preservation vary widely, from immaculately preserved to mere skeletons.

Due to the unusual conditions of peat bogs – highly acidic water, low temperature, and a lack of oxygen – the soft tissue of bog bodies can be remarkably well-preserved in comparison to typical ancient human remains. The high levels of acidity can tan their skin and preserve internal organs, but inversely dissolve the calcium phosphate of bone. The natural protein keratin, present in skin, hair, nails, wool and leather, is resistant to the acidic conditions of peat bogs.

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Keratin in the context of Talon (anatomy)

A claw is a curved, pointed appendage found at the end of a toe or finger in most amniotes (mammals, reptiles, birds). Some invertebrates such as beetles and spiders have somewhat similar fine, hooked structures at the end of the leg or tarsus for gripping a surface as they walk. The pincers of crabs, lobsters and scorpions, more formally known as their chelae, are sometimes called claws.

A true claw is made of a hard protein called keratin. Claws are used to catch and hold prey in carnivorous mammals such as cats and dogs, but may also be used for such purposes as digging, climbing trees, self-defense and grooming, in those and other species.

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Keratin in the context of Baleen

Baleen is a filter-feeding system inside the mouths of baleen whales. To use baleen, the whale first opens its mouth underwater to take in water. The whale then pushes the water out, and animals such as krill are filtered by the baleen and remain as a food source for the whale. Baleen is similar to bristles and consists of keratin, the same substance found in human fingernails, skin and hair. Baleen is a skin derivative. Some whales, such as the bowhead whale, have baleen of differing lengths. Other whales, such as the gray whale, only use one side of their baleen. These baleen bristles are arranged in plates across the upper jaw of whales.

Depending on the species, a baleen plate can be 0.5 to 3.5 m (1.6 to 11.5 ft) long, and weigh up to 90 kg (200 lb). Its hairy fringes are called baleen hair or whalebone hair. They are also called baleen bristles, which in sei whales are highly calcified, with calcification functioning to increase their stiffness. Baleen plates are broader at the gumline (base). The plates have been compared to sieves or Venetian blinds.

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Keratin in the context of Mohair

Mohair (pronounced /ˈmhɛər/) originated from the Arabic word [مهير] and it is a fabric or yarn made from the hair of the Angora goat (not Angora wool from the fur of the Angora rabbit). Both durable and resilient, mohair is lustrous with high sheen, and is often blended to add these qualities to a textile. Mohair takes dye exceptionally well. It feels warm in winter due to excellent insulating properties, while moisture-wicking keeps it cool in summer. It is durable, naturally elastic, flame-resistant and crease-resistant. It is considered a luxury fiber, like cashmere, alpaca, angora, and silk, and is more expensive than most sheep's wool.

Mohair is composed mostly of keratin, a protein in the hair, wool, horns and skin of all mammals, but mohair's special properties are unique to the Angora goat. While it has scales like wool, they are not fully developed, thus, mohair feels different from common or standard wool.

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Keratin in the context of Hair growth

The growth of human hair occurs everywhere on the external body except for the soles of the feet, the palms of the hands, the lips, the backs of the ears, some external genital areas, the navel, and, apart from eyelashes, the eyelids. Hair is a stratified squamous keratinized epithelium made of multi-layered flat cells whose rope-like filaments provide structure and strength to the hair shaft. The protein keratin makes up hair and stimulates hair growth. Hair follows a specific growth cycle with three distinct and concurrent phases: anagen, catagen, and telogen. Each phase has specific characteristics that determine the length of the hair.

The body has different types of hair, including vellus hair and androgenic hair, each with its own type of cellular construction. This varied construction gives the hair unique characteristics, serving specific purposes, mainly warmth (redundant in modern humans) and physical protection. Most humans develop the longest thickest hair on their scalps and (mostly observed in males) faces. This hair will usually grow to several feet, but some humans develop much longer hair.

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Keratin in the context of Alpha-keratin

Alpha-keratin, or α-keratin, is a type of keratin found in mammalian vertebrates. This protein is the primary component in hairs, horns, claws, nails and the epidermis layer of the skin. α-keratin is a fibrous structural protein, meaning it is made up of amino acids that form a repeating secondary structure. The secondary structure of α-keratin is very similar to that of a traditional protein α-helix and forms a coiled coil. Due to its tightly wound structure, it can function as one of the strongest biological materials and has various functions in mammals, from predatory claws to hair for warmth. α-keratin is synthesized through protein biosynthesis, utilizing transcription and translation, but as the cell matures and is full of α-keratin, it dies, creating a strong non-vascular unit of keratinized tissue.

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Keratin in the context of Epidermis (zoology)

In zoology, the epidermis is an epithelium (sheet of cells) that covers the body of a eumetazoan (animal more complex than a sponge). Eumetazoa have a cavity lined with a similar epithelium, the gastrodermis, which forms a boundary with the epidermis at the mouth.

Sponges have no epithelium, and therefore no epidermis or gastrodermis. The epidermis of a more complex invertebrate is just one layer deep, and may be protected by a non-cellular cuticle. The epidermis of a higher vertebrate has many layers, and the outer layers are reinforced with keratin and then die.

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Keratin in the context of Amniote

Amniotes are tetrapod vertebrate animals belonging to the clade Amniota, a large group that comprises the vast majority of living terrestrial and semiaquatic vertebrates. Amniotes evolved from amphibious stem tetrapod ancestors during the Carboniferous period. Amniota is defined as the smallest crown clade (the group including all descendants of the last common ancestor) containing humans, the Greek tortoise, and the Nile crocodile.Amniotes represent a crucial evolutionary step in vertebrate history, marking the transition from aquatic to fully terrestrial life.

Amniotes are distinguished from the other living tetrapod clade — the non-amniote lissamphibians (frogs/toads, salamanders/newts and caecilians) — by: the development of three extraembryonic membranes (amnion for embryonic protection, chorion for gas exchange, and allantois for metabolic waste disposal or storage); internal fertilization; thicker and keratinized skin; costal respiration (breathing by expanding/constricting the rib cage); the presence of adrenocortical and chromaffin tissues as a discrete pair of glands near their kidneys; more complex kidneys; the presence of an astragalus for better extremity range of motion; the diminished role of skin breathing; and the complete loss of metamorphosis, gills, and lateral lines.

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