Karpathos-Kasos (Greek: Περιφερειακή Ενότητα Καρπάθου - Ηρωϊκής Νήσου Κάσου, literally: "Regional Unit of Karpathos - Heroic Island of Kasos") is one of the regional units of Greece. It is part of the region of South Aegean. The regional unit covers the islands of Karpathos, Kasos, Saria and several smaller islands in the Aegean Sea.
Karpathos (Greek: Κάρπαθος, pronounced [ˈkarpaθos]), also Carpathos, is the second largest of the Greek Dodecanese islands, in the southeastern Aegean Sea. Together with the neighboring smaller Saria Island it forms the municipality of Karpathos, which is part of the regional unit Karpathos-Kasos. Because of its remote location, Karpathos has preserved many peculiarities of dress, customs and dialect, the last resembling those of Crete and Cyprus. The island has also been called Carpathus in Latin and Scàrpanto in Italian.
Kasos (/ˈkɑːsoʊs/; Greek: Κάσος, pronounced [ˈka̠so̞s]), also Casos, is a Greek island municipality in the Dodecanese. It is the southernmost island in the Aegean Sea, and is part of the regional unit Karpathos-Kasos. The capital of the island is Fri. As of 2021, its population was 1,223.