Karankawa in the context of "Colorado River (Texas)"

Spanish Texas was one of the interior provinces of the colonial Viceroyalty of New Spain from 1519 until 1821. Spain claimed ownership of the region in 1519. Slave raids by Spaniards into what became Texas began in the 16th century and created an atmosphere of antagonism with Native Americans (Indians) which would cause endless difficulties for the Spanish in the future. Spain did not attempt to establish a permanent presence until after France established the colony of Fort Saint Louis in 1685. In 1688, the French colony failed due to internal dissention and attacks by the Karankawa Indians. In 1690, responding to fear of French encroachment, Spanish explorer Alonso de León escorted several Catholic missionaries to east Texas, where they established the first mission in Texas. That attempt to establish a Spanish colony failed due to the hostility of the Caddo Indians.

The Spanish returned to southeastern Texas in 1716, establishing several missions and a presidio to maintain a buffer between Spanish territory and the Louisiana district of New France. San Antonio was founded in 1719 and became the capital and largest settlement of Spanish Tejas.

The French colonization of Texas started in 1685 when Robert Cavelier de La Salle intended to found the colony at the mouth of the Mississippi River, but inaccurate maps and navigational errors caused his ships to anchor instead 400 miles (640 km) to the west, off the coast of Texas. The colony survived until 1688. The present-day town of Inez is near the fort's site. The colony faced numerous difficulties during its brief existence, including Native American raids, epidemics, and harsh conditions. From that base, La Salle led several expeditions to find the Mississippi River. These did not succeed, but La Salle did explore much of the Rio Grande and parts of East Texas.

During one of his absences in 1686, the colony's last ship was wrecked, leaving the colonists unable to obtain resources from the French colonies of the Caribbean. As conditions deteriorated, La Salle realized the colony could survive only with help from the French settlements in Illinois Country to the north, along the Mississippi and Illinois rivers. La Salle's last expedition ended along the Brazos River in early 1687, when he and five of his men were murdered during a mutiny. Although a handful of men, led by Henri Joutel, reached Illinois Country, help never made it to the fort. Most of the remaining members of the colony were killed during a Karankawa raid in late 1688, though four children survived after being adopted as captives. Although the colony lasted only three years, it established France's claim to possession of the region that is now Texas. The United States later claimed, unsuccessfully, this region as part of the Louisiana Purchase because of the early French colony.