Joint United Nations Programme on HIV/AIDS in the context of "AIDS"

The human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system. Without treatment, it can lead to a spectrum of conditions including acquired immunodeficiency syndrome (AIDS). It is a preventable disease. It can be managed with treatment and become a manageable chronic health condition. While there is no cure or vaccine for HIV, antiretroviral treatment can slow the course of the disease, and, if used before significant disease progression, can extend the life expectancy of someone living with HIV to a nearly standard level. An HIV-positive person on treatment can expect to live a normal life, and die with the virus, not of it. Effective treatment for HIV-positive people (people living with HIV) involves a life-long regimen of medicine to suppress the virus, making the viral load undetectable.

Treatment is recommended as soon as the diagnosis is made. An HIV-positive person who has an undetectable viral load as a result of long-term treatment has effectively no risk of transmitting HIV sexually. Campaigns by UNAIDS and organizations around the world have communicated this as Undetectable = Untransmittable.

HIV-positive people, seropositive people or people who live with HIV are people infected with the human immunodeficiency virus (HIV), a retrovirus which if untreated may progress to acquired immunodeficiency syndrome (AIDS).

According to estimates by the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS), 38.4 million people were infected with HIV at the end of 2021. That same year, some 1.5 million people became newly infected, and 650,000 died of AIDS-related causes, including 98,000 children. More than two-thirds of new HIV infections are in sub-Saharan Africa.

HIV/AIDS in Lesotho constitutes a very serious threat to Basotho and to Lesotho's economic development. Since its initial detection in 1986, HIV/AIDS has spread at alarming rates in Lesotho. In 2000, King Letsie III declared HIV/AIDS a natural disaster. According to the Joint United Nations Programme on HIV/AIDS (UNAIDS) in 2016, Lesotho's adult prevalence rate of 25% is the second highest in the world, following Eswatini.

HIV has affected the majority of the general population, while disproportionately affecting the rural, working-age population. The spread of HIV in Lesotho is compounded by cultural practices, serodiscordancy, and gender-based violence. Lack of developed sexual education programs in schools places the young demographic at increased risk of HIV infection.

An AIDS orphan is a child who became an orphan because one or both parents died from AIDS.

In statistics from the Joint United Nations Programme on HIV/AIDS (UNAIDS), the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF), the term is used for a child whose mother has died due to AIDS before the child's 15th birthday, regardless of whether the father is still alive. As a result of this definition, one study estimated that 80% of all AIDS orphans still have one living parent.