Jean-Baptiste Debret in the context of "Lithograph"

During and after the European colonization of the Americas, European settlers practiced widespread enslavement of Indigenous peoples. In the 15th century, the Spanish introduced chattel slavery through warfare and the cooption of existing systems. A number of other European powers followed suit, and from the 15th through the 19th centuries, between two and five million Indigenous people were enslaved, which had a devastating impact on many Indigenous societies, contributing to the overwhelming population decline of Indigenous peoples in the Americas.

After the decolonization of the Americas, the enslavement of Indigenous peoples continued into the 19th century in frontier regions of some countries, notably parts of Brazil, Peru Northern Mexico, and the Southwestern United States. Some Indigenous groups adopted European-style chattel slavery during the colonial period, most notably the "Five Civilized Tribes" in the United States, however far more Indigenous groups were involved in the selling of Indigenous slaves to Europeans.

Slavery in Brazil began long before the first Portuguese settlement. Later, colonists were heavily dependent on indigenous labor during the initial phases of settlement to maintain the subsistence economy, and natives were often captured by expeditions of bandeirantes. The importation of African slaves began midway through the 16th century, but the enslavement of indigenous peoples continued well into the 17th and 18th centuries.

During the Atlantic slave trade era, Brazil imported more enslaved Africans than any other country in the world. Out of the 12 million Africans who were forcibly brought to the New World, approximately 5.5 million were brought to Brazil between 1540 and the 1860s. The mass enslavement of Africans played a pivotal role in the country's economy and was responsible for the production of vast amounts of wealth. The inhumane treatment and forced labor of enslaved Africans remains a significant part of Brazil's history and its ongoing struggle with systemic racism. Until the early 1850s, most enslaved African people who arrived on Brazilian shores were forced to embark at West Central African ports, especially in Luanda (present-day Angola).