‘Iṣmah or ‘Isma (Arabic: عِصْمَة; literally, "protection") is the concept of incorruptible innocence, immunity from sin, or moral infallibility in Islamic theology, and which is especially prominent in Shia Islam. In Shia theology, ismah is characteristic of prophets, imams, and angels. When attributed to human beings, ismah means "the ability of avoiding acts of disobedience, in spite of having the power to commit them". Along with a pure constitution, excellent qualities, firmness against opponents, and tranquility (as-Sakinah), ismah is a divine grace bestowed by God.
An infallible (Arabic: معصوم, romanized: ma'sūm) is someone who is free from error in leading people to belief, in perceiving divine knowledge, and in practical matters. Prophets must be immune from all errors and sins in order to perform their mission of upholding and promoting the divine religion, interpreting the Qur'an, and establishing a wholesome social system.