Isla del Frío (Spanish for 'cold island') is a small uninhabited island off the southern central coast of the main island of Puerto Rico. Together with Caja de Muertos, Gatas, Morrillito, Ratones, Cardona, and Isla de Jueyes, Isla del Frío is one of seven islands ascribed to the municipality of Ponce. Like Isla de Jueyes, the island is considered part of barrio Vayas.