Isabella Jagiellon (Hungarian: Izabella királyné; Polish: Izabela Jagiellonka; Lithuanian: Izabelė Jogailaitė; 18 January 1519 – 15 September 1559) was a princess of the Kingdom of Poland and of the Grand Duchy of Lithuania, and later also the Queen consort of Hungary. She was the oldest child of Sigismund I the Old, King of Poland and Grand Duke of Lithuania, and his Italian wife Bona Sforza.
In 1539, she married John Zápolya, Voivode of Transylvania and King of Hungary. At the time Hungary was contested between Ferdinand of Austria who wanted to add it to the Habsburg domains (see Royal Hungary), local nobles who wanted to keep Hungary independent (see Eastern Hungarian Kingdom), and Sultan Suleiman the Magnificent who saw it as a vassal state of the Ottoman Empire (see also Little War in Hungary). While Isabella's marriage lasted only a year and a half, it did produce a male heir – John Sigismund Zápolya born just two weeks before his father's death in July 1540.