Interstate 35E (I-35E) is an Interstate Highway in the US state of Minnesota, passing through downtown Saint Paul. It is one of two through routes for I-35 through the Twin Cities of Minneapolis and Saint Paul, the other being I-35W through Minneapolis. Thus, both ends of I-35E are shared with I-35W and I-35.
During the early years of the Interstate Highway System, branching Interstates with directional suffixes, such as N, S, E, and W, were common nationwide. On every other Interstate nationwide, these directional suffixes have been phased out by redesignating the suffixed route numbers with a loop or spur route number designation (such as I-270 in Maryland, which was once I-70S) or, in some cases, were assigned a different route number (such as I-76, which was once I-80S). In the case of I-35 in the Twin Cities area, since neither branch is clearly the main route and both branches return to a unified Interstate beyond the cities of Minneapolis and Saint Paul, officials at the American Association of State Highway and Transportation Officials (AASHTO) have allowed the suffixes of E and W in Minnesota to remain in the present day. I-35 also splits into I-35E and I-35W in Dallas–Fort Worth, Texas, for similar reasons as the I-35 split in the Minneapolis–Saint Paul area.