Human digestive system in the context of "Gastric juice"

Human waste (or human excreta) refers to the waste products of the human digestive system, menses, and human metabolism including urine and feces. As part of a sanitation system that is in place, human waste is collected, transported, treated and disposed of or reused by one method or another, depending on the type of toilet being used, ability by the users to pay for services and other factors. Fecal sludge management is used to deal with fecal matter collected in on-site sanitation systems such as pit latrines and septic tanks.

The sanitation systems in place differ vastly around the world, with many people in developing countries having to resort to open defecation where human waste is deposited in the environment, for lack of other options. Improvements in "water, sanitation and hygiene" (WASH) around the world is a key public health issue within international development and is the focus of Sustainable Development Goal 6.

In agriculture, grazing is a method of animal husbandry whereby domestic livestock are allowed outdoors to free range (roam around) and consume wild vegetations in order to convert the otherwise indigestible (by human gut) cellulose within grass and other forages into meat, milk, wool and other animal products. Grazing is often done on lands that are unsuitable for arable farming, although there are occasions where arable lands and even prior farmlands are intentionally kept or converted to pastures to raise commercially valuable grazing animals.

Farmers may employ many different strategies of grazing for optimum production: grazing may be continuous, seasonal, or rotational within a grazing period. Longer rotations are found in ley farming, alternating arable and fodder crops; in rest rotation, deferred rotation, and mob grazing, giving grasses a longer time to recover or leaving land fallow. Patch-burn sets up a rotation of fresh grass after burning with two years of rest. Conservation grazing proposes to use grazing animals to improve the biodiversity of a site.

Digestion is the breakdown of large insoluble food compounds into small water-soluble components so that they can be absorbed into the blood plasma. In certain organisms, these smaller substances are absorbed through the small intestine into the blood stream. Digestion is a form of catabolism that is often divided into two processes based on how food is broken down: mechanical and chemical digestion. The term mechanical digestion refers to the physical breakdown of large pieces of food into smaller pieces which can subsequently be accessed by digestive enzymes. Mechanical digestion takes place in the mouth through mastication and in the small intestine through segmentation contractions. In chemical digestion, enzymes break down food into the small compounds that the body can use.

In the human digestive system, food enters the mouth and mechanical digestion of the food starts by the action of mastication (chewing), a form of mechanical digestion, and the wetting contact of saliva. Saliva, a liquid secreted by the salivary glands, contains salivary amylase, an enzyme which starts the digestion of starch in the food. The saliva also contains mucus, which lubricates the food; the electrolyte hydrogencarbonate (HCO₃), which provides the ideal conditions of pH for amylase to work; and other electrolytes (Na, K, Cl). About 30% of starch is hydrolyzed into disaccharide in the oral cavity (mouth). After undergoing mastication and starch digestion, the food will be in the form of a small, round slurry mass called a bolus. It will then travel down the esophagus and into the stomach by the action of peristalsis. Gastric juice in the stomach starts protein digestion. Gastric juice mainly contains hydrochloric acid and pepsin. In infants and toddlers, gastric juice also contains rennin to digest milk proteins. As the first two chemicals may damage the stomach wall, mucus and bicarbonates are secreted by the stomach. They provide a slimy layer that acts as a shield against the damaging effects of chemicals like concentrated hydrochloric acid while also aiding lubrication. Hydrochloric acid provides acidic pH for pepsin. At the same time protein digestion is occurring, mechanical mixing occurs by peristalsis, which is waves of muscular contractions that move along the stomach wall. This allows the mass of food to further mix with the digestive enzymes. Pepsin breaks down proteins into peptides or proteoses, which are further broken down into dipeptides and amino acids by enzymes in the small intestine. Studies suggest that increasing the number of chews per bite increases relevant gut hormones and may decrease self-reported hunger and food intake.

Lactobacillus is a genus of gram-positive within the Lactobacillaceae family, aerotolerant anaerobes or microaerophilic, rod-shaped, non-spore-forming bacteria. Until 2020, the genus Lactobacillus comprised over 260 phylogenetically, ecologically, and metabolically diverse species; a taxonomic revision of the genus assigned lactobacilli to 25 genera (see § Taxonomy below).

Lactobacillus species constitute a significant component of the human and animal microbiota at a number of body sites, such as the digestive system and the female genital system. In women of European ancestry, Lactobacillus species are normally a major part of the vaginal microbiota. Lactobacillus forms biofilms in the vaginal and gut microbiota, allowing them to persist in harsh environmental conditions and maintain ample populations. Lactobacillus exhibits a mutualistic relationship with the human body, as it protects the host against potential invasions by pathogens, and in turn, the host provides a source of nutrients. Lactobacilli are among the most common probiotic found in food such as yogurt, and the bacteria are diverse in their application in maintaining human well-being, by helping to treat diarrhea, vaginal infections, and skin disorders such as eczema.

Pepsin /ˈpɛpsɪn/ is an endopeptidase that breaks down proteins into smaller peptides and amino acids. It is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food. Pepsin is an aspartic protease, using a catalytic aspartate in its active site.

It is one of three principal endopeptidases (enzymes cutting proteins in the middle) in the human digestive system, the other two being chymotrypsin and trypsin. There are also exopeptidases which remove individual amino acids at both ends of proteins (carboxypeptidases produced by the pancreas and aminopeptidases secreted by the small intestine). During the process of digestion, these enzymes, each of which is specialized in severing links between particular types of amino acids, collaborate to break down dietary proteins into their components, i.e., peptides and amino acids, which can be readily absorbed by the small intestine. The cleavage specificity of pepsin is broad, but some amino acids like tyrosine, phenylalanine and tryptophan increase the probability of cleavage.

On 3 June 1989, at 22:20 IRST, Ruhollah Khomeini, the founder and first supreme leader of the Islamic Republic of Iran (IRI), died in Jamaran, Greater Tehran, aged 89 after spending eleven days at a private hospital, near his residency, after suffering five heart attacks in ten days. Sources put his age at 89, and list the cause of death as bleeding in the digestive system. As a mark of respect, Iran's government ordered all schools to be closed on Sunday and declared 40 days of mourning and said schools would be closed for five days. Pakistan declared ten days of national mourning, Syria announced seven days of mourning, Afghanistan, Lebanon, and India announced three days of mourning. Iraq also expressed condolences.

Khomeini was given a state funeral and buried at the Behesht-e Zahra (The Paradise of Zahra) cemetery in south Tehran. It was estimated that around 10 million people participated in his funeral, one-sixth of the population of Iran, which is the largest proportion of a population ever to attend a funeral procession and also one of the largest gatherings in human history.