Huayna Cápac in the context of Paccha Duchicela

Qullasuyu (Quechua and Aymara spelling, listen; Collasuyu, Kholla Suyu; Spanish: Collasuyo) was the southeastern provincial region of the Inca Empire. Qullasuyu is the region of the Qulla and related specifically to the native Qulla Quechuas who primarily resided in areas such as Cochabamba and Potosí. Most Aymara territories which are now largely incorporated into the modern South American states of northern Chile, Peru, Bolivia and the Argentine northwest were annexed during the reign of Sapa Inca Huayna Cápac in the sixteenth century.

Recently, there have been movements to form a "Greater Qullasuyu" (or Qullana Suyu Marka) which would incorporate a territory similar to the former Tawantinsuyu in extent. This ideal has been proposed by the office of the Apu Mallku and the parliament of the Qullana. Qullasuyu was the largest of the four suyu (or "quarters", the largest divisions of the Inca empire) in terms of area. This suyu encompassed the Bolivian Altiplano and much of the southern Andes, running down into northwest Argentina and as far south as the Maule river near modern Santiago, Chile. Along with Kuntisuyu, it was part of the Hurin Suyukuna or "Lower Quarters" of the empire.

Manco Inca Yupanqui (c. 1515 – 1544) was the founder and first Sapa Inca of the independent Neo-Inca State in Vilcabamba, although he was originally a puppet Inca Emperor installed by the Spaniards. He was also known as Manco II and Manco Cápac II. He was one of the sons of Huayna Cápac and a younger brother of Huáscar.