The House of Farnese (/fɑːrˈneɪzi, -zeɪ/, also US: /-eɪsi/, Italian: [farˈneːze, -eːse]) was an influential family in Renaissance Italy. The titles of Duke of Parma and Piacenza, Duke of Latera and Duke of Castro were held by various members of the family.
Its most important members included Pope Paul III, Alessandro Farnese (a cardinal), Alexander Farnese, Duke of Parma and Piacenza (a military commander and Governor of the Spanish Netherlands), and Elisabeth Farnese, who became Queen of Spain and whose legacy was brought to her Bourbon descendants.