Hotel Theresa in the context of "125th Street (Manhattan)"

125th Street, co-named Martin Luther King Jr. Boulevard is a two-way street that runs east–west in the New York City borough of Manhattan, from First Avenue on the east to Marginal Street, a service road for the Henry Hudson Parkway along the Hudson River in the west. It is often considered to be the "Main Street" of Harlem.

Notable buildings along 125th Street include the Apollo Theater, the Adam Clayton Powell Jr. State Office Building, the Hotel Theresa, the Studio Museum in Harlem, the Mount Morris Bank Building, Harlem Commonwealth Council, the Harlem Children's Zone, the Church of St. Joseph of the Holy Family, and the former West End Theatre, now home to the La Gree Baptist Church.

The Adam Clayton Powell Jr. State Office Building, originally the Harlem State Office Building, is a nineteen-story, high-rise office building located at 163 West 125th Street at the corner of Adam Clayton Powell Jr. Boulevard in the Harlem neighborhood of Manhattan, New York City. It is named after Adam Clayton Powell Jr, the first African-American elected to Congress from New York. It was designed by the African-American architecture firm of Ifill Johnson Hanchard in the shape of an African mask in the Brutalist style. It is the tallest building in Harlem, overtaking the nearby Hotel Theresa.