Hemichordate in the context of "Metazoans"

Animals are multicellular, eukaryotic organisms comprising the biological kingdom Animalia (/ˌænɪˈmeɪliə/). With few exceptions, animals consume organic material, breathe oxygen, have myocytes and are able to move, can reproduce sexually, and grow from a hollow sphere of cells, the blastula, during embryonic development. Animals form a clade, meaning that they arose from a single common ancestor. Over 1.5 million living animal species have been described, of which around 1.05 million are insects, over 85,000 are molluscs, and around 65,000 are vertebrates. It has been estimated there are as many as 7.77 million animal species on Earth. Animal body lengths range from 8.5 μm (0.00033 in) to 33.6 m (110 ft). They have complex ecologies and interactions with each other and their environments, forming intricate food webs. The scientific study of animals is known as zoology, and the study of animal behaviour is known as ethology.

The animal kingdom is divided into five major clades, namely Porifera, Ctenophora, Placozoa, Cnidaria and Bilateria. Most living animal species belong to the clade Bilateria, a highly proliferative clade whose members have a bilaterally symmetric and significantly cephalised body plan, and the vast majority of bilaterians belong to two large clades: the protostomes, which includes organisms such as arthropods, molluscs, flatworms, annelids and nematodes; and the deuterostomes, which include echinoderms, hemichordates and chordates, the latter of which contains the vertebrates. The much smaller basal phylum Xenacoelomorpha have an uncertain position within Bilateria.

Deuterostomes (from Greek: lit. 'second mouth') are bilaterian animals of the superphylum Deuterostomia (/ˌdjuːtərəˈstoʊmi.ə/), typically characterized by their anus forming before the mouth during embryonic development. Deuterostomia comprises three phyla: Chordata, Echinodermata, Hemichordata, and the extinct clade Cambroernida.

In deuterostomes, the developing embryo's first opening (the blastopore) becomes the anus and cloaca, while the mouth is formed at a different site later on. This was initially the group's distinguishing characteristic, but deuterostomy has since been discovered among protostomes as well. The deuterostomes are also known as enterocoelomates, because their coelom develops through pouching of the gut, enterocoely.

Hox genes, a subset of homeobox genes, are a group of related genes that specify regions of the body plan of an embryo along the head-tail axis of animals. Hox proteins encode and specify the characteristics of 'position', ensuring that the correct structures form in the correct places of the body. For example, Hox genes in insects specify which appendages form on a segment (for example, legs, antennae, and wings in fruit flies), and Hox genes in vertebrates specify the types and shape of vertebrae that will form. In segmented animals, Hox proteins thus confer segmental or positional identity, but do not form the actual segments themselves.

Studies on Hox genes in ciliated larvae have shown they are only expressed in future adult tissues. In larvae with gradual metamorphosis the Hox genes are activated in tissues of the larval body, generally in the trunk region, that will be maintained through metamorphosis. In larvae with complete metamorphosis the Hox genes are mainly expressed in juvenile rudiments and are absent in the transient larval tissues. The larvae of the hemichordate species Schizocardium californicum and the pilidium larva of Nemertea do not express Hox genes.

The dorsal nerve cord is an anatomical feature found in all chordates, mainly in the subphyla Vertebrata and Cephalochordata, as well as in some hemichordates. It is one of the five embryonic features unique to all chordates, the other four being a notochord, a post-anal tail, an endostyle, and pharyngeal slits.

All chordates (vertebrates, tunicates and cephalochordates) have dorsal hollow nerve cords.