The Italian Wars were a series of conflicts fought between 1494 and 1559 in the Italian Peninsula, with subsidiary theatres in Flanders, the Rhineland and Mediterranean Sea. A product of the long-running French–Habsburg rivalry, its primary belligerents were France versus the Holy Roman Empire and Spain, supported by numerous Italian states at different stages, along with England, and the Ottoman Empire.
The collapse of the Italic League in 1492 allowed Charles VIII of France to invade Naples in 1494, which drew in Spain and the Holy Roman Empire. Although he was forced to withdraw in 1495, ongoing political divisions among the Italian states made them a battleground in the struggle for European domination between France and the Habsburgs.