Guayas River in the context of Coat of arms of Ecuador

Guayaquil (Spanish pronunciation: [ɡwaʝaˈkil] ), officially Santiago de Guayaquil, is the largest city in Ecuador and also the nation's economic capital and main port. The city is the capital of Guayas Province and the seat of Guayaquil Canton. The city is located on the west bank of the Guayas River, which flows into the Pacific Ocean at the Gulf of Guayaquil.

With a population of 2,746,403 inhabitants, it is the most populous city in the country, and the fifth largest in the Andean Community. However, its urban fabric extends beyond its official urban parishes, encompassing nearby cities and parishes; thus, the Guayaquil metropolitan area reaches a population of 3,618,450, making it the most populous urban agglomeration in the nation, and also the fifth in the Andean Community. As the largest city, it is one of the two main development poles of the country—alongside Quito, the national capital—hosting Ecuador’s main business, financial, cultural, and sports institutions.

The Gulf of Guayaquil is a large body of water of the Pacific Ocean in western South America. Its northern limit is the city of Santa Elena, in Ecuador, and its southern limit is Cabo Blanco, in Peru.

The gulf takes its name from the city of Guayaquil. Rivers of both Ecuador and Peru empty in the Gulf of Guayaquil, like the Guayas River, the Jubones River, the Zarumilla River and the Tumbes River.

Santay Island (Spanish Isla Santay) is a 2200 ha. island located in Guayas, Ecuador. It is part of the Durán Canton. It is surrounded by the Guayas River and populated by 47 families living there since the 1950s and before.

The Daule River is a river in Ecuador, in Guayas Province. At Guayaquil, it joins the Babahoyo River; from that point the confluence becomes the Guayas River.