Grosse Isle (French: Grosse Île, pronounced [ɡʁos il], "big island") is an island located in the St. Lawrence River in Quebec, Canada. It is one of the islands of the 21-island Isle-aux-Grues archipelago. It is part of the municipality of Saint-Antoine-de-l'Isle-aux-Grues, located in the Chaudière-Appalaches region of the province.
Also known as Grosse Isle (the famine) and the Irish Memorial National Historic Site, the island was the site of an immigration depot which housed predominantly Irish immigrants coming to Canada to escape the Great Famine of 1845–1849. In 1832, the Lower Canadian Government had previously set up this depot to contain an earlier cholera epidemic that was believed to be caused by the large influx of European immigrants, and the station was reopened in the mid-19th century to accommodate Irish immigrants who had contracted typhus during their voyages. Thousands of Irish were quarantined on Grosse Isle from 1832 to 1848.