The Great Lakes region of Northern America is a binational Canadian–American region centered on the Great Lakes that includes the U.S. states of Illinois, Indiana, Michigan, Minnesota, New York, Ohio, Pennsylvania, and Wisconsin and the Canadian province of Ontario. It encompasses both the Upper Midwest and parts of the Mid-Atlantic. Canada's Quebec province is at times included as part of the region because the St. Lawrence River watershed is part of the continuous hydrologic system. The region forms a distinctive historical, economic, and cultural identity. A portion of the region also encompasses the Great Lakes megalopolis.
State and provincial governments are represented in the Conference of Great Lakes and St. Lawrence Governors and Premiers, which also serves as the Secretariat to the Great Lakes St. Lawrence Compact and the Great Lakes–Saint Lawrence River Basin Sustainable Water Resources Agreement.