Seam Zone (Hebrew: מרחב התפר) is a term used to refer to a land area in the Israeli-occupied West Bank located east of the Green Line and west of Israel's separation barrier, populated largely by Israelis in settlements such as Alfei Menashe, Ariel, Beit Arye, Modi'in Illit, Giv'at Ze'ev, Ma'ale Adumim, Beitar Illit and Efrat.
As of 2006, it was estimated that about 57,000 Palestinians lived in villages located in enclaves in the seam zone, separated from the rest of the West Bank by the Wall (according to the ICJ Wall Case opinion). The United Nations estimated that if the series of walls, fences, barbed wire and ditches is completed along its planned route, about a third of West Bank Palestinians will be affected—274,000 will be located in enclaves in the seam zone and about 400,000 separated from their fields, jobs, schools and hospitals. The Supreme Court of Israel ordered changes to the barrier route to reduce the number of people leaving or affected by the seam zone—according to the court verdict the number now stands at 35,000.