The destruction of Native American peoples, cultures, and languages has been characterized by some as genocide. Debates are ongoing as to whether the entire process or only specific periods or events meet the definitions of genocide. Many of these definitions focus on intent, while others focus on outcomes. Raphael Lemkin, who coined the term "genocide", considered the displacement of Native Americans by European settlers as a historical example of genocide. While description as genocide has found increasing acceptance within Indigenous and genocide studies, mainstream scholarship on US and Native American history has largely rejected it, preferring to describe it as ethnic cleansing or certain events as genocidal.
Historians have long debated the pre-European population of the Americas. In 2023, historian Ned Blackhawk suggested that Northern America's population (Including modern-day Canada and the United States) had halved from 1492 to 1776 from about 8 million people (all Native American in 1492) to under 4 million (predominantly white in 1776). Russell Thornton estimated that by 1800, some 600,000 Native Americans lived in the regions that would become the modern United States and declined to an estimated 250,000 by 1890 before rebounding.