Gangrene in the context of "Raynaud's syndrome"

Cambyses II was the second King of Kings of the Achaemenid Empire, reigning 530 to 522 BCE. He was the son of and successor to Cyrus the Great (r. 550 – 530 BC); his mother was Cassandane. His relatively brief reign was marked by his conquests in North Africa, notably Egypt, which he took by defeating pharaoh Psamtik III (r. 526–525 BC) at the battle of Pelusium in 525 BC. After his victory in Egypt, he expanded the empire's holdings in Africa by taking Cyrenaica, the coastal region of eastern Libya. In the spring of 522 BC, Cambyses had to leave Egypt hastily to put down a revolt in Persia.

En route in Syria (Eber-Nari), Cambyses somehow received a thigh wound; it soon became gangreneous. Cambyses died three weeks later in Agbatana, likely the modern city of Hama. He died childless, and was thus succeeded by his younger brother Bardiya. Bardiya ruled for a short time, and was then overthrown by Darius the Great (r. 522–486 BC), who went on to increase the power of the Achaemenids even further.

Necrosis (from Ancient Greek νέκρωσις (nékrōsis) 'death') is a form of cell injury which results in the premature death of cells in living tissue by autolysis. The term "necrosis" came about in the mid-19th century and is commonly attributed to German pathologist Rudolf Virchow, who is often regarded as one of the founders of modern pathology. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated digestion of cell components. In contrast, apoptosis is a naturally occurring programmed and targeted cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal.

Cellular death due to necrosis does not follow the apoptotic signal transduction pathway, but rather various receptors are activated and result in the loss of cell membrane integrity and an uncontrolled release of products of cell death into the extracellular space. This initiates an inflammatory response in the surrounding tissue, which attracts leukocytes and nearby phagocytes which eliminate the dead cells by phagocytosis. However, microbial damaging substances released by leukocytes would create collateral damage to surrounding tissues. This excess collateral damage inhibits the healing process. Thus, untreated necrosis results in a build-up of decomposing dead tissue and cell debris at or near the site of the cell death. A classic example is gangrene. For this reason, it is often necessary to remove necrotic tissue surgically, a procedure known as debridement.

Amputation is the removal of a limb or other body part by trauma, medical illness, or surgery. As a surgical measure, it is used to control pain or a disease process in the affected limb, such as malignancy or gangrene. In some cases, it is carried out on individuals as a preventive surgery for such problems. A special case is that of congenital amputation, a congenital disorder, where fetal limbs have been cut off by constrictive bands. In some countries, judicial amputation is currently used to punish people who commit crimes. Amputation has also been used as a tactic in war and acts of terrorism; it may also occur as a war injury. In some cultures and religions, minor amputations or mutilations are considered a ritual accomplishment. When done by a person, the person executing the amputation is an amputator. The oldest evidence of this practice comes from a skeleton found buried in Liang Tebo cave, East Kalimantan, Indonesian Borneo dating back to at least 31,000 years ago, where it was done when the amputee was a young child. A prosthesis or a bioelectric replantation restores sensation of the amputated limb.

William McKinley, the 25th president of the United States, was shot on the grounds of the Pan-American Exposition in the Temple of Music in Buffalo, New York, on September 6, 1901, six months into his second term. He was shaking hands with the public when an anarchist, Leon Czolgosz, shot him twice in the abdomen. McKinley died on September 14 of gangrene caused by the wounds. He was the third American president to be assassinated, following Abraham Lincoln in 1865 and James A. Garfield in 1881.

McKinley enjoyed meeting the public and was reluctant to accept the security available to his office. Secretary to the President George B. Cortelyou feared that an assassination attempt would take place during a visit to the Temple of Music and took it off the schedule twice, but McKinley restored it each time.

Josip Broz Tito, President of Yugoslavia and leader of the League of Communists of Yugoslavia, died on 4 May 1980 following a prolonged illness. His state funeral was held four days later on 8 May, drawing a significant amount of statesmen from Western, Eastern and Non-Aligned countries across the world. The attendees included four kings, six princes, 22 prime ministers, 31 presidents, and 47 ministers of foreign affairs. In total, 128 countries out of the 154 UN members at the time were represented. Also present were delegates from seven multilateral organizations, six movements and forty political parties.

Tito had become increasingly ill throughout 1979. On 7 January and again on 11 January 1980, Tito was admitted to the University Medical Centre in Ljubljana, the capital city of SR Slovenia, with circulation problems in his legs. His left leg was amputated soon afterwards due to arterial blockages, and he died of gangrene at the Medical Centre Ljubljana on 4 May 1980 at 3:05 pm, three days short of his 88th birthday. The Plavi voz, Tito's personal train, brought his body to Belgrade where it lay in state at the Federal Parliament building until the funeral.

Gas gangrene (also known as clostridial myonecrosis) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. About 1,000 cases of gas gangrene are reported yearly in the United States.

Myonecrosis is a condition of necrotic damage, specific to muscle tissue. It is often seen in infections with C. perfringens or any of myriad soil-borne anaerobic bacteria. Bacteria cause myonecrosis by specific exotoxins. These microorganisms are opportunistic and, in general, enter the body through significant skin breakage. Gangrenous infection by soil-borne bacteria was common in the combat injuries of soldiers well into the 20th century, because of non-sterile field surgery and the basic nature of care for severe projectile wounds.