Freedom Tower (Miami) in the context of U.S. Route 1 in Florida

Miami is the second-most populous city in the U.S. state of Florida, and its metropolitan area, with a population of 6.4 million, is the largest in the state. Miami has the third-largest skyline in the United States, after New York City and Chicago, and the fourth largest in North America. It has over 400 high-rises, 78 of which are taller than 492 feet (150 m), with six more that are topped out. The tallest building in the city is the 85-story Panorama Tower, completed in 2017, which rises 868 feet (265 m) in Miami's Brickell district. The top ten tallest buildings in Florida are located in Miami, and the top twenty are all in the city's metropolitan area.

The first significant tall building in Miami is considered to be the six-story Burdine's Department Store, built in 1912, while the 17-story, Mediterranean Revival Freedom Tower, completed in 1925, is the city's best-known early skyscraper. For much of the 20th century, Miami had a relatively modest skyline compared to other major American cities. Beginning in the mid-1990s, Miami underwent a large residential high-rise boom that transformed its skyline, and expanded it to the Brickell and Edgewater neighborhoods. Development accelerated in the mid-2000s, until the Great Recession brought an end to the boom. The skyscraper boom resumed in the mid-2010s, owing to the city's continued population growth and investment, with Miami overtaking Houston as the city with the largest skyline in the southern United States, and has continued into the 2020s.

Marco Rubio, then the junior United States senator from Florida, formally announced his 2016 presidential campaign on April 13, 2015, at the Freedom Tower in Downtown Miami. Early polling showed Rubio, who was considered a potential candidate for vice president by Republican presidential nominee Mitt Romney in 2012, as a frontrunner candidate for the Republican nomination for president of the United States in 2016 since at least the end of the 2012 election. Rubio was the second Cuban American to run for president, with Republican Ted Cruz announcing his campaign three weeks earlier. He suspended his campaign on March 15, 2016, after finishing second in Florida's primary.

Later that year, the Republican nominee, Donald Trump, was elected president in the presidential election. Eight years later, after Trump's re-election to a non-consecutive term, he nominated Rubio as Secretary of State.