Francisco de Almeida in the context of John II of Portugal

The State of India, also known as the Portuguese State of India or Portuguese India, was a state of the Portuguese Empire founded seven years after the discovery of the sea route to the Indian subcontinent by Vasco da Gama, a subject of the Kingdom of Portugal. The capital of Portuguese India served as the governing centre of a string of military forts and maritime ports scattered along the coasts of the Indian Ocean.

Francisco de Almeida, the first viceroy, established his base of operations at Fort Manuel in the Malabar region, after the Kingdom of Cochin negotiated to become a protectorate of Portugal in 1505. With the Portuguese conquest of Goa from the Bijapur Sultanate in 1510, Goa became the major anchorage for the Armadas arriving in India. The capital of the viceroyalty was transferred from Cochin to Goa in 1530. From 1535, Mumbai (Bombay) was a harbour of Portuguese India, known as Bom Bahia, until it was handed over to Charles II of England in 1661 as part of the dowry of Catherine de Braganza. The expression "State of India" began regularly appearing in documents in the mid-16th century.

The government of Portuguese India (Portuguese: Índia Portuguesa) started on 12 September 1505, seven years after the Portuguese discovery of the sea route to India by Vasco da Gama, with the nomination of the first Portuguese viceroy Francisco de Almeida, then settled at Cochin. Until 1752, the name India included all Portuguese possessions in the Indian Ocean, from Southern Africa to Southeast Asia, governed – either by a viceroy or governor – from its headquarters, established in Old Goa since 1510. In 1752 Portuguese Mozambique was granted its own government, and in 1844 the Portuguese government of India ceased administering the territory of Portuguese Macau, Solor and Portuguese Timor, seeing itself thus confined to a reduced territorial possessions along the Konkan, Canara and Malabar Coasts, which would further be reduced to the present-day state of Goa and the union territory of Daman. Portuguese control ceased in Dadra and Nagar Haveli in 1954, and finally ceased in Goa in 1961, when the area was occupied by the Republic of India (although Portugal only recognised the occupation after the Carnation Revolution in 1974, by a treaty signed on 31 December 1974). This ended four and a half centuries of Portuguese rule in parts – though tiny – of India.

It may be noted that during the term of the monarchy, the title of the head of the Portuguese government in India ranged from "governor" to "viceroy". The title of viceroy would only be assigned to members of the nobility; it was formally terminated in 1774, although it has later been given sporadically to be decisively ended after 1835, as shown below.