Francisco Pizarro in the context of "Conquistadors"

The Spanish colonization of the Americas began in 1493 on the Caribbean island of Hispaniola (now Haiti and the Dominican Republic) after the initial 1492 voyage of Genoese mariner Christopher Columbus under license from Queen Isabella I of Castile. These overseas territories of the Spanish Empire were under the jurisdiction of Crown of Castile until the last territory was lost in 1898. Spaniards saw the dense populations of Indigenous peoples as an important economic resource and the territory claimed as potentially producing great wealth for individual Spaniards and the crown. Religion played an important role in the Spanish conquest and incorporation of indigenous peoples, bringing them into the Catholic Church peacefully or by force. The crown created civil and religious structures to administer the vast territory. Spanish men and women settled in greatest numbers where there were dense indigenous populations and the existence of valuable resources for extraction.

The Spanish Empire claimed jurisdiction over the New World in the Caribbean and North and South America, with the exception of Brazil, ceded to Portugal by the Treaty of Tordesillas. Other European powers, including England, France, and the Dutch Republic, took possession of territories initially claimed by Spain. Although the overseas territories under the jurisdiction of the Spanish crown are now commonly called "colonies" the term was not used until the second half of 18th century. The process of Spanish settlement, now called "colonization" and the "colonial era" are terms contested by scholars of Latin America and more generally.

A caudillo (/kɔːˈdiː(l)joʊ, kaʊˈ-/ kaw-DEE(L)-yoh, kow-, Spanish: [kawˈðiʎo]; Old Spanish: cabdillo, from Latin capitellum, diminutive of caput "head") is a type of personalist leader wielding military and political power. There is no precise English translation for the term, though it is often used interchangeably with "military dictator," "warlord" and "strongman". The term is historically associated with Spain and Hispanic America, after virtually all of the regions in the latter won independence in the early nineteenth century.

The roots of caudillismo may be tied to the framework of rule in medieval and early modern Spain during the Reconquista from the Moors. Spanish conquistadors such as Hernán Cortés and Francisco Pizarro exhibit characteristics of the caudillo, being successful military leaders, having mutual reliance on the leader and their supporters, and rewarding them for their loyalty. An important characteristic of the caudillo is their charisma, which drew in followers who could be utilized to change the political climate and shape state-formation in the post colonial era. The followers of caudillos, called gauchos, were common people whom the caudillos could charm and persuade into joining their cause. Often the caudillo would take on the role of the provider as a substitute for the shortcomings of those in the government. It created a type of father-child bond between the caudillo and gaucho that strengthened loyalties and made the caudillos powerful. However, the paternalist view towards the relationship between the caudillo and the gaucho assumes that the caudillo has all of the power in the relationship and ignores that much of that power comes from the gaucho's decision to follow a particular caudillo.

The Incas were most notable for establishing the Inca Empire which was centered in modern-day Peru and Chile. It was about 4,000 kilometres (2,500 mi) from the northern to southern tip. The Inca Empire lasted from 1438 to 1533. It was the largest Empire in America throughout the Pre-Columbian era. The Inca state was originally founded by Manco Cápac in the early 1200s, and is known as the Kingdom of Cuzco. Under subsequent rulers, through strategic alliances and conquests, it expanded beyond Cusco and into the Sacred Valley. Their territory then rapidly grew under the 9th Sapa Inca (emperor), Pachacuti and his descendents.

Over the course of the Inca Empire, the Inca used conquest and peaceful assimilation to incorporate the territory of modern-day Peru, followed by a large portion of western South America, into their empire, centered on the Andean mountain range. However, shortly after the Inca Civil War, the last Sapa Inca of the Inca Empire, Atahualpa, was captured and killed on the orders of the conquistador Francisco Pizarro, marking the beginning of Spanish rule. The remnants of the empire retreated to the remote jungles of Vilcabamba and established the small Neo-Inca State, which was conquered by the Spanish in 1572.

Conquistadors (/kɒnˈk(w)ɪstədɔːrz/, US also /-ˈkiːs-, kɒŋˈ-/) or conquistadores (Spanish: [koŋkistaˈðoɾes]; Portuguese: [kõkiʃtɐˈðoɾɨʃ, kõkistɐˈdoɾis]; lit. 'conquerors') were Spanish and Portuguese colonizers who explored, traded with and conquered parts of the Americas, Africa, Asia, and Oceania during the Age of Discovery. Sailing beyond the Iberian Peninsula, they established numerous colonies and trade routes, and brought much of the New World under the dominion of Spain and Portugal.

After Christopher Columbus's arrival in the West Indies in 1492, the Spanish, usually led by hidalgos from the west and south of Spain, began building a colonial empire in the Caribbean using colonies such as Santo Domingo, Cuba, and Puerto Rico as their main bases. From 1519 to 1521, Hernán Cortés led the Spanish conquest of the Aztec Empire, ruled by Moctezuma II. From the territories of the Aztec Empire, conquistadors expanded Spanish rule to northern Central America and parts of what is now the southern and western United States, and from Mexico sailing the Pacific Ocean to the Spanish East Indies. Other Spanish conquistadors took over the Inca Empire after crossing the Isthmus of Panama and sailing the Pacific to northern Peru. From 1532 to 1572, Francisco Pizarro succeeded in subduing this empire in a manner similar to Cortés. Subsequently, Spanish conquistadores used Peru as a base for conquering much of Ecuador and Chile. Central Colombia, home of the Muisca, was conquered by licentiate Gonzalo Jiménez de Quesada, and its northern regions were explored by Rodrigo de Bastidas, Alonso de Ojeda, Juan de la Cosa, Pedro de Heredia and others. For southwestern Colombia, Bolivia, and Argentina, Spanish conquistadores from Peru combined parties with other conquistadors arriving more directly from the Caribbean and Río de la Plata-Paraguay respectively. These conquests founded the basis for modern Hispanic America and the Hispanosphere.

The Spanish conquest of the Inca Empire, also known as the Conquest of Peru, was one of the most important campaigns in the Spanish colonization of the Americas. After years of preliminary exploration and military skirmishes, 168 Spanish soldiers under conquistador Francisco Pizarro, along with his brothers in arms and their indigenous allies, captured the last Sapa Inca, Atahualpa, at the Battle of Cajamarca in 1532. It was the first step in a long campaign that took decades of fighting but ended in Spanish victory in 1572 and colonization of the region as the Viceroyalty of Peru. The conquest of the Inca Empire (called "Tahuantinsuyu" or "Tawantinsuyu" in Quechua, meaning "Realm of the Four Parts"), led to spin-off campaigns into present-day Chile and Colombia, as well as expeditions to the Amazon Basin and surrounding rainforest.

When the Spanish arrived at the borders of the Inca Empire in 1528, it spanned a considerable area and was by far the largest of the four grand pre-Columbian civilizations. Extending southward from the Ancomayo, which is now known as the Patía River, in southern present-day Colombia to the Maule River in what would later be known as Chile, and eastward from the Pacific Ocean to the edge of the Amazonian jungles, it covered some of the most mountainous terrains on Earth. In less than a century, the Inca had expanded their empire from about 400,000 km (150,000 sq mi) in 1448 to 1,800,000 km (690,000 sq mi) in 1528, just before the arrival of the Spanish. This vast area of land varied greatly in culture and climate. Because of the diverse cultures and geography, the Inca allowed many areas of the empire to be governed under the control of local leaders, who were watched and monitored by Inca officials. Under the administrative mechanisms established by the Inca, all parts of the empire answered to, and were ultimately under the direct control of, the Inca Emperor. Scholars estimate that the population of the Inca Empire was between 12 and 16 million.

The Inca society was the society of the Inca civilization in Peru. The Inca Empire, which lasted from 1438 to 1533 A.D., represented the height of this civilization. The Inca state was known as the Kingdom of Cusco before 1438. Over the course of the empire, the rulers used conquest and peaceful assimilation to incorporate a large portion of western South America, centered on the Andes mountain ranges. The empire proved relatively short-lived however: by 1533, Atahualpa, the last Sapa Inca (emperor) of the Inca Empire, was killed on the orders of the conquistador Francisco Pizarro, marking the beginning of Spanish rule. The last Inca stronghold, the Neo-Inca State in Vilcabamba, was conquered by the Spanish in 1572.

The Spanish conquest of New Granada refers to the conquest between 1525 and 1540 by the Spanish monarchy of the Chibchan-speaking nations of modern-day Colombia and Panama, mainly the Muisca and Tairona that inhabited present-day Colombia, beginning the Spanish colonization of the Americas. It is estimated that around 5.25 million people died as a result of Spanish Conquest, either by disease or direct conflict. This represents 87.5% of the Pre-Columbian population of Colombia.