Francesco II Sforza (4 February 1495 – 1 November 1535) was Duke of Milan from 1521 until his death. He became duke of Milan after Emperor Charles V reconquered it from the French. He fought at the Battle of Bicocca against the French, but in 1526 joined the League of Cognac with Francis I of France. Surviving a poisoning, he married Christina of Denmark, but died childless. He was the last member of the Sforza family to rule Milan.