Fort Saint-Louis, Texas, was founded in 1685 by French explorer René-Robert Cavelier de La Salle and members of his expedition, including Jesuit missionary Zenobius Membre, on the banks of Garcitas Creek, a few kilometers inland from the mouth of the Lavaca River. La Salle had intended to establish the colony at the mouth of the Mississippi, but inaccurate charts and navigational errors led his ships more than six hundred kilometers (more than 372 miles) to the west, to the coast of Texas.
The colony's brief existence was fraught with difficulties, including the hostility of the natives, epidemics and harsh climatic conditions. Conscious of his original mission, La Salle led several expeditions to find the Mississippi, which led him to explore much of the Río Grande and eastern Texas. During one of his absences, in 1686, the colony's last ship was destroyed, prohibiting the colonists from obtaining supplies from French possessions in the Caribbean Sea. His last expedition took place on the Brazos River in early 1687. It was then that La Salle and five of his men were murdered, due to rivalries within the group he was leading.