Foot-and-mouth disease in the context of "Culling"

The word "murrain" /ˈmʌrɪn/ (like an archaic use of the word "distemper") is an antiquated term covering various infectious diseases affecting cattle and sheep. The word originates from Middle English moreine or moryne, in parallel to Late Latin morina ("plague"), a probable derivative of Latin mori ("to die").

The word "murrain", much like the word "pestilence", did not refer to a specific disease but rather served as an umbrella term for what veterinary science now recognises as a number of different diseases with high morbidity and mortality, such as rinderpest, erysipelas, foot-and-mouth disease, anthrax, and streptococcus infections. Some of these livestock diseases can also affect humans. The term "murrain" also referred to an epidemic of such a disease.

A capsid is the protein shell of a virus, enclosing its genetic material. It consists of several oligomeric (repeating) structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or may not correspond to individual proteins, are called capsomeres. The proteins making up the capsid are called capsid proteins or viral coat proteins (VCP). The virus genomic component inside the capsid, along with occasionally present virus core protein, is called the virus core. The capsid and core together are referred to as a nucleocapsid (cf. also virion).

Capsids are broadly classified according to their structure. The majority of the viruses have capsids with either helical or icosahedral structure. Some viruses, such as bacteriophages, have developed more complicated structures due to constraints of elasticity and electrostatics. The icosahedral shape, which has 20 equilateral triangular faces, approximates a sphere, while the helical shape resembles the shape of a spring, taking the space of a cylinder but not being a cylinder itself. The capsid faces may consist of one or more proteins. For example, the foot-and-mouth disease virus capsid has faces consisting of three proteins named VP1–3.

Plum Island Animal Disease Center (PIADC) is a United States federal research facility dedicated to the study of foreign animal diseases of livestock. It is a national laboratory of the Department of Homeland Security (DHS) Directorate for Science and Technology (S&T), and operates as a partnership with the U.S. Department of Agriculture (USDA). The facility's director is Larry Barrett.

Isolated on Plum Island off the eastern tip of Long Island, New York, the center has been tasked with protecting America's livestock from animal diseases since 1954. It is the only facility in the country authorized to work with live foot-and-mouth disease (FMD) samples, and specializes in the study of FMD and African swine fever. At the height of the Cold War, study of biological weapons for use against livestock was conducted at the site, ending in 1969 when President Nixon declared an end to the United States' offensive bioweapons program. Today the facility maintains laboratories up to biosafety level 3, and has remained controversial as a result of its high-risk work and proximity to the New York metropolitan area.