Florence, Alabama in the context of University of North Alabama

The Natchez Trace Parkway is a limited-access national parkway in the Southeastern United States that commemorates the historic Natchez Trace and preserves sections of that original trail. Its central feature is a two-lane road that extends 444 miles (715 km) from Natchez, Mississippi, to Nashville, Tennessee. Access to the parkway is limited, with more than 50 access points in Mississippi, Alabama, and Tennessee. The southern end of the route is in Natchez at its intersection with Liberty Road, and the northern end is northeast of Fairview, Tennessee, in the suburban community of Pasquo, at an intersection with Tennessee State Route 100. In addition to Natchez and Nashville, larger cities along the route include Jackson and Tupelo, Mississippi, and Florence, Alabama.

The Rosenbaum House is a single-family house designed by architect Frank Lloyd Wright and built for Stanley and Mildred Rosenbaum in Florence, Alabama, United States. A noted example of his Usonian house concept, it is the only Wright building in Alabama, and is one of only 26 pre-World War II Usonian houses. Wright scholar John Sergeant called it "the purest example of the Usonian." It is currently a house museum.

Alternate U.S. Route 72 (US 72 Alt.) exists in Alabama on the south side of the Tennessee River between Muscle Shoals and Decatur, while US 72 follows on the north side of the river between Florence and Athens. US 72 Alt. crosses the Tennessee River at Decatur, along with US 31, and follows the entire route of Interstate 565 (I-565). SR-20 was co-signed with US 72 Alt. from Muscle Shoals to Huntsville but has since been truncated to the junction of I-65 just east of Decatur.

Originally, US 72 Alt. turned off SR-20 on to SR-53 / Jordan Lane in Huntsville and followed it north one mile (1.6 km) to rejoin with US 72. With the completion of I-565 in the early 1990s, US 72 Alt. was routed along with I-565 to the termination of I-565 at US 72 at Chapman Mountain.

State Route 20 (SR 20) is a 73.978-mile-long (119.056 km) state highway in the northern part of the U.S. state of Alabama. It travels from the Tennessee state line, where it continues as Tennessee State Route 69, northwest of Florence, east to Interstate 65 (I-65), east of Decatur. It crosses the Tennessee River at Florence (with US 43, US 72, SR 17, and SR 157) and also at Decatur (with US 31 and US 72 Alt.)

US 72 Alt. follows SR 20 from the intersection with US 72 at Muscle Shoals to I-65 east of Decatur, the entire stretch being four-laned.