Filipa Moniz Perestrelo in the context of "Porto Santo Island"

Christopher Columbus (/kəˈlʌmbəs/; between 25 August and 31 October 1451 – 20 May 1506) was an Italian explorer and navigator from the Republic of Genoa who completed four Spanish-based voyages across the Atlantic Ocean sponsored by the Catholic Monarchs, opening the way for the widespread European exploration and colonization of the Americas. His expeditions were the first known European contact with the Caribbean and Central and South America.

The name Christopher Columbus is the anglicization of the Latin Christophorus Columbus. Growing up on the coast of Liguria, he went to sea at a young age and traveled widely, as far north as the British Isles and as far south as what is now Ghana. He married Portuguese noblewoman Filipa Moniz Perestrelo, who bore a son, Diego, and was based in Lisbon for several years. He later took a Castilian mistress, Beatriz Enríquez de Arana, who bore a son, Ferdinand.

Diego Columbus (Portuguese: Diogo Colombo; Spanish: Diego Colón; Italian: Diego Colombo; 1479/1480 – February 23, 1526) was a navigator and explorer under the kings of Castile and Aragón. He served as the 2nd admiral of the Indies, 2nd viceroy of the Indies and 4th governor of the Indies as a vassal to the kings of Castile and Aragón. He was the eldest son of Christopher Columbus and his wife Filipa Moniz Perestrelo.

He was born in Portugal, either in Porto Santo in 1479 or 1480, or in Lisbon in 1474. He spent most of his adult life trying to regain the titles and privileges granted to his father for his explorations and then denied in 1500. He was greatly aided in this goal by his marriage to María de Toledo y Rojas, niece of the 2nd Duke of Alba, who was the cousin of King Ferdinand.