The Syrian Wars were a series of six wars between the Seleucid Empire and the Ptolemaic Kingdom of Egypt, successor states to Alexander the Great's empire, during the 3rd and 2nd centuries BC over the region then called Coele-Syria, one of the few avenues into Egypt. These conflicts drained the material and manpower of both parties and led to their eventual destruction and conquest by Rome and Parthia. They are briefly mentioned in the biblical Books of the Maccabees.
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Fifth Syrian War in the context of Ptolemy V Epiphanes
Ptolemy V Epiphanes Eucharistus (Greek: Πτολεμαῖος Ἐπιφανής Εὐχάριστος, Ptolemaĩos Epiphanḗs Eukháristos "Ptolemy the Manifest, the Beneficent"; 9 October 210–September 180 BC) was the King of Ptolemaic Egypt from July or August 204 BC until his death in 180 BC.
Ptolemy V, the son of Ptolemy IV and Arsinoe III, inherited the throne at the age of five when his parents died in suspicious circumstances. The new regent, Agathocles, was widely reviled and was toppled by a revolution in 202 BC, but the series of regents who followed proved incompetent and the kingdom was paralysed. The Seleucid king Antiochus III and the Antigonid king Philip V took advantage of the kingdom's weakness to begin the Fifth Syrian War (202–196 BC), in which the Ptolemies lost all their territories in Asia Minor and the Levant, as well as most of their influence in the Aegean Sea. Simultaneously, Ptolemy V faced a widespread Egyptian revolt (206–185 BC) led by the self-proclaimed pharaohs Horwennefer and Ankhwennefer, which resulted in the loss of most of Upper Egypt and parts of Lower Egypt as well.