Ferdinand I of Naples in the context of Treaty of Lodi

Gjon II Kastrioti (Italian: Ioanne Castrioto, Giovanni Castrioto; 1456 – 2 August 1514), was an Albanian prince and the son of Gjergj Kastrioti Skanderbeg, the Albanian national hero, and of Andronika Arianiti, daughter of Gjergj Arianiti. He was for a short time Lord of Krujë after his father's death, then Duke of San Pietro in Galatina (1485), Count of Soleto, Signore of Monte Sant'Angelo and San Giovanni Rotondo. In 1495, Ferdinand I of Naples gave him the title of the Signore of Gagliano del Capo and Oria. While in his early teens, he was forced to leave the country after the death of his father in 1468. He is also known for his role in the Albanian Rebellion of 1481–1484, when, after reaching the Albanian coast from Italy and settling in Himara, he led a rebellion against the Ottoman Empire. In June 1481, he supported forces of Ivan Crnojević to successfully recapture Zeta from the Ottomans. He was unable to re-establish the Kastrioti Principality and liberate Albania from the Ottomans, and he retired in Italy after three years of war in 1484.

Pope Callixtus III (Italian: Callisto III, Valencian: Calixt III, Spanish: Calixto III; 31 December 1378 – 6 August 1458), born Alonso de Borja, but referred to in English-language accounts as Alfonso de Borgia as a member of the House of Borgia, was head of the Catholic Church and ruler of the Papal States from 8 April 1455 to his death, in August 1458.

Borgia spent his early career as a professor of law at the University of Lleida; he later served as a diplomat for the kings of Aragon. He became a tutor for King Alfonso V's illegitimate son Ferdinand. After arranging a reconciliation between Alfonso and Pope Martin V, Borgia was made Bishop of Valencia.

Pope Innocent VIII (Latin: Innocentius VIII; Italian: Innocenzo VIII; 1432 – 25 July 1492), born Giovanni Battista Cybo (or Cibo), was head of the Catholic Church and ruler of the Papal States from 29 August 1484 to his death, in July 1492. Son of the viceroy of Naples, Cybo spent his early years at the Neapolitan court. He became a priest in the retinue of Cardinal Calandrini, half-brother to Pope Nicholas V (1447–55); Bishop of Savona under Pope Paul II; and with the support of Cardinal Giuliano Della Rovere he was made a cardinal by Pope Sixtus IV. After intense politicking by Della Rovere, Cybo was elected pope in 1484. King Ferdinand I of Naples had supported Cybo's competitor, Rodrigo Borgia. The following year, Pope Innocent supported the barons in their failed revolt.

During his papacy, Pope Innocent issued a papal bull on witchcraft named Summis desiderantes affectibus. In March 1489, Cem, the captive brother of Bayezid II, the sultan of the Ottoman Empire, came into Innocent's custody. Viewing his brother as a rival, the Sultan paid Pope Innocent not to set him free. The amount he paid to Pope Innocent was 120,000 crowns (an amount equal to all of the annual revenue to the Vatican) in addition to some holy relics and another sum of money to be paid annually. Any time the Sultan threatened war against the Christian Balkans, Innocent threatened to release his brother. On 28 January 1495, Cem was released by Innocent's successor, Pope Alexander VI, into the custody of the army of King Charles VIII of France.