Experimental_autoimmune_encephalomyelitis

⭐ Core Definition: Experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis, sometimes experimental allergic encephalomyelitis (EAE), is an animal model of brain inflammation. It is an inflammatory demyelinating disease of the central nervous system (CNS). It is mostly used with rodents and is widely studied as an animal model of the human CNS demyelinating diseases, including multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM). EAE is also the prototype for T-cell-mediated autoimmune disease in general.

EAE development was motivated by observations during the convalescence from viral diseases by Thomas M. Rivers, D. H. Sprunt and G. P. Berry in 1933. Their findings upon a transfer of inflamed patient tissue to primates was published in the Journal of Experimental Medicine. An acute monophasic illness, it has been suggested that EAE is far more similar to ADEM than to MS.

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Experimental autoimmune encephalomyelitis in the context of Relapsing–remitting

Relapsing–remitting is a medical term referring to a presentation of disease symptoms that become worse over time (relapsing), followed by periods of less severe symptoms that do not completely cease (partial remitting). The term is used to describe a type of multiple sclerosis called relapsing–remitting multiple sclerosis, where unpredictable relapses are followed by remission for months to years.

The term is also used to describe palindromic rheumatism in the context of rheumatoid arthritis, catatonia, lupus, mental disorders, and experimental autoimmune encephalomyelitis.

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Experimental autoimmune encephalomyelitis in the context of "Demyelinating disease"

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⭐ Core Definition: Experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis in the context of Relapsing–remitting