Euphorion of Chalcis (Greek: Εὐφορίων ὁ Χαλκιδεύς) was a Greek poet and grammarian, born at Chalcis in Euboea in the 126th olympiad (276–272 BC).
Euphorion spent much of his life in Athens, where he amassed great wealth. After studying philosophy with Lacydes and Prytanis, he became the student and eromenos of the poet Archeboulus. About 221 he was invited by Antiochus the Great to the court of Syria. He assisted in the formation of the royal Library of Antioch, of which he held the post of librarian till his death. He wrote mythological epics (the Thrax), amatory elegies, epigrams and a satirical poem (Arae, "curses") after the manner of the Ibis of Callimachus.
