Mesopotamia is a historical region of West Asia situated within the TigrisâEuphrates river system, in the northern part of the Fertile Crescent. It corresponds roughly to the territory of modern Iraq and forms the eastern geographic boundary of the modern Middle East. Just beyond it lies southwestern Iran, where the region transitions into the Persian plateau, marking the shift from the Arab world to Iran. In the broader sense, the historical region of Mesopotamia also includes parts of present-day Iran (southwest), Turkey (southeast), Syria (northeast), and Kuwait.
Mesopotamia is the site of the earliest developments of the Neolithic Revolution from around 10,000 BC. It has been identified as having "inspired some of the most important developments in human history, including the invention of the wheel, the planting of the first cereal crops, the development of cursive script, mathematics, astronomy, and agriculture". It is recognised as the cradle of some of the world's earliest civilizations.