El Abra in the context of Bogotá savanna

The Spanish conquest of the Muisca took place from 1537 to 1540. The Muisca were the inhabitants of the central Andean highlands of Colombia before the arrival of the Spanish conquistadors. They were organised in a loose confederation of different rulers; the psihipqua of Muyquytá, with his headquarters in Funza, the hoa of Hunza, the iraca of the sacred City of the Sun Sugamuxi, the Tundama of Tundama, and several other independent caciques. The most important rulers at the time of the conquest were psihipqua Tisquesusa, hoa Eucaneme, iraca Sugamuxi and Tundama in the northernmost portion of their territories. The Muisca were organised in small communities of circular enclosures (ca in their language Muysccubbun; literally "language of the people"), with a central square where the bohío of the cacique was located. They were called "Salt People" because of their extraction of salt in various locations throughout their territories, mainly in Zipaquirá, Nemocón, and Tausa. For the main part self-sufficient in their well-organised economy, the Muisca traded with the European conquistadors valuable products as gold, tumbaga (a copper-silver-gold alloy), and emeralds with their neighbouring indigenous groups. In the Tenza Valley, to the east of the Altiplano Cundiboyacense where the majority of the Muisca lived, they extracted emeralds in Chivor and Somondoco. The economy of the Muisca was rooted in their agriculture with main products maize, yuca, potatoes, and various other cultivations elaborated on elevated fields (in their language called tá). Agriculture had started around 3000 BCE on the Altiplano, following the preceramic Herrera Period and a long epoch of hunter-gatherers since the late Pleistocene. The earliest archaeological evidence of inhabitation in Colombia, and one of the oldest in South America, has been found in El Abra, dating to around 12,500 years BP.

The main part of the Muisca civilisation was concentrated on the Bogotá savanna, a flat high plain in the Eastern Ranges of the Andes, far away from the Caribbean coast. The savanna was an ancient lake, that existed until the latest Pleistocene and formed a highly fertile soil for their agriculture. The Muisca were a deeply religious civilisation with a polytheistic society and an advanced astronomical knowledge, which was represented in their complex lunisolar calendar. Men and women had specific and different tasks in their relatively egalitarian society; while the women took care of the sowing, preparation of food, the extraction of salt, and the elaboration of mantles and pottery, the men were assigned to harvesting, warfare, and hunting. The guecha warriors were tasked with the defence of the Muisca territories, mainly against their western neighbours; the Muzo ("Emerald People") and the bellicose Panche. To impress their enemies, the Muisca warriors wore mummies of important ancestors on their backs, while fighting. In their battles, the men used spears, poisoned arrows, and golden knives.