Eileen Collins in the context of Cessna T-41 Mescalero

Space Shuttle Columbia (OV-102) was a Space Shuttle orbiter manufactured by Rockwell International and operated by NASA. Named after the first American ship to circumnavigate the globe, and the female personification of the United States, Columbia was the first of five Space Shuttle orbiters to fly in space, debuting the Space Shuttle launch vehicle on its maiden flight on April 12, 1981 and becoming the first spacecraft to be re-used after its first flight when it launched on STS-2 on November 12, 1981. As only the second full-scale orbiter to be manufactured after the Approach and Landing Test vehicle Enterprise, Columbia retained unique external and internal features compared with later orbiters, such as test instrumentation and distinctive black chines. In addition to a heavier aft fuselage and the retention of an internal airlock throughout its lifetime, these made Columbia the heaviest of the five spacefaring orbiters: around 1,000 kilograms (2,200 pounds) heavier than Challenger and 3,600 kilograms (7,900 pounds) heavier than Endeavour when originally constructed. Columbia also carried ejection seats based on those from the SR-71 during its first six flights until 1983, and from 1986 onwards carried an imaging pod on its vertical stabilizer.

During its 22 years of operation, Columbia was flown on 28 missions in the Space Shuttle program, spending over 300 days in space and completing over 4,000 orbits around Earth. NASA's flagship orbiter, Columbia often flew flights dedicated to scientific research in orbit following the loss of Challenger in 1986. Columbia was used for eleven of the fifteen flights of Spacelab laboratories, all four United States Microgravity Payload missions, and the only flight of Spacehab's Research Double Module. Columbia flew many of the longest duration space shuttle missions, all dedicated to scientific research. The only space shuttle that could rival Columbia's long missions was Endeavour, which flew the STS-67 mission that lasted for nearly 17 days. In 1992, NASA modified Columbia to be able to fly some of the longest missions in the Shuttle Program history using the Extended Duration Orbiter pallet. The orbiter used the pallet in thirteen of the pallet's fourteen flights, which aided lengthy stays in orbit for scientific and technological research missions. The longest duration flight of the Shuttle Program, STS-80, was flown with Columbia in 1996, at over 17 days in orbit. Columbia was also used to deploy the first ever satellites into orbit by the Shuttle on STS-5, retrieve the Long Duration Exposure Facility and deploy the Chandra observatory, which was the heaviest payload ever carried by the Space Shuttle. Columbia also carried into space the first female commander of an American spaceflight mission, the first ESA astronaut, the first female astronaut of Indian origin, and the first Israeli astronaut.

STS-93 in 1999 marked the 95th launch of the Space Shuttle, the 26th launch of Columbia, and the 21st night launch of a Space Shuttle. Eileen Collins became the first female shuttle Commander on this flight. Its primary mission was to launch the Chandra X-ray Observatory, the heaviest payload ever carried by the Space Shuttle system, at 22,780 kilograms (50,222 lb).

STS-93 would be Columbia's last mission until March 2002. During the interim, Columbia would be out of service for upgrading and would only fly again on STS-109. The launch was originally scheduled for 20 July, but it was aborted at T−7 seconds. The successful launch of the flight occurred three days later.