Dracunculiasis in the context of Parasitic infection


Dracunculiasis in the context of Parasitic infection

⭐ Core Definition: Dracunculiasis

Dracunculiasis, also called Guinea-worm disease, is a parasitic infection by the Guinea worm (Dracunculus medinensis). A person becomes infected by drinking water contaminated with Guinea-worm larvae that reside inside copepods (a type of small crustacean). Stomach acid digests the copepod and releases the Guinea worm larva, which penetrates the digestive tract and escapes into the body. Around a year later, the adult female worm migrates to an exit site – usually the lower leg – and induces an intensely painful blister on the skin. Eventually, the blister bursts, creating a painful wound from which the worm gradually emerges over several weeks. The wound remains painful throughout the worm's emergence, disabling the affected person for the three to ten weeks it takes the worm to emerge. The female worm releases larvae when the host submerges the wound in water in attempts to relieve the pain, thus continuing the life cycle.

There is no medication to treat or prevent dracunculiasis. Instead, the mainstay of treatment is the careful wrapping of the emerging worm around a small stick or gauze to encourage and speed up its exit. Each day, a few more centimeters of the worm emerge, and the stick is turned to maintain gentle tension. Too much tension can break and kill the worm in the wound, causing severe pain and swelling. Dracunculiasis is a disease of extreme poverty, occurring in places with poor access to clean drinking water. Prevention efforts center on filtering drinking water to remove copepods as well as public education campaigns to discourage people from soaking affected limbs in sources of drinking water, as this action allows the worms to spread their larvae.

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Dracunculiasis in the context of Eradication of infectious diseases

The eradication of infectious diseases is the reduction of the prevalence of an infectious disease in the global host population to zero.

Two infectious diseases have successfully been eradicated: smallpox in humans, and rinderpest in ruminants. There are four ongoing programs, targeting the human diseases polio, yaws, dracunculiasis (Guinea worm), and malaria. Five more infectious diseases have been identified as of April 2008 as potentially eradicable with current technology by the Carter Center International Task Force for Disease Eradicationmeasles, mumps, rubella, lymphatic filariasis (elephantiasis), and cysticercosis (pork tapeworm).

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Dracunculiasis in the context of Mebendazole

Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm infection, hookworm infections, guinea worm infections and hydatid disease, among others. It has been used for treatment of giardiasis but is not a preferred agent. It is taken by mouth.

Mebendazole is usually well tolerated. Common side effects include headache, vomiting, and ringing in the ears. If used at large doses it may cause bone marrow suppression. It is unclear if it is safe in pregnancy. Mebendazole is a broad-spectrum antihelminthic agent of the benzimidazole type.

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Dracunculiasis in the context of Metronidazole

Metronidazole, sold under the brand name Flagyl and Metrogyl among others, is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis. It is an option for a first episode of mild-to-moderate Clostridioides difficile colitis if vancomycin or fidaxomicin is unavailable. Metronidazole is available orally (by mouth), as a cream or gel, and by slow intravenous infusion (injection into a vein).

Common side effects include nausea, a metallic taste, loss of appetite, and headaches. Occasionally seizures or allergies to the medication may occur.

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Dracunculiasis in the context of Carter Center International Task Force for Disease Eradication

The Carter Center is a nongovernmental, nonprofit organization founded in 1982 by former U.S. president Jimmy Carter. He and his wife Rosalynn Carter partnered with Emory University after his defeat in the 1980 United States presidential election. The center is located in a shared building adjacent to the Jimmy Carter Library and Museum on 37 acres (150,000 m) of parkland, on the site of the razed neighborhood of Copenhill, two miles (3 km) from downtown Atlanta, Georgia. The library and museum are owned and operated by the United States National Archives and Records Administration, while the center is governed by a Board of Trustees, consisting of business leaders, educators, former government officials, and philanthropists.

The Carter Center's goal is to advance human rights and alleviate human suffering. The center has projects across 80 countries including election monitoring, democratic institution-building, conflict mediation, and human rights advocacy. It also leads efforts to treat neglected tropical diseases, spearheading the campaign to eradicate dracunculiasis, as well as treating onchocerciasis, trachoma, lymphatic filariasis, and malaria.

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